Borodi Paul Gabriel, Slevin Mark
Department of Ophthalmology, Dr. Constantin Papilian Military Emergency Hospital, Cluj-Napoca, Romania;
Rom J Morphol Embryol. 2025 Jan-Mar;66(1):51-59. doi: 10.47162/RJME.66.1.04.
The retina consists of one of the body's most delicate organs, being sensitive to various metabolic disturbances, vascular abnormalities and inflammatory processes. Age-related macular degeneration (AMD) impacts millions of people worldwide and represents a notable cause of blindness. Chronic inflammation, implicated in several degenerative diseases including Parkinson's and Alzheimer's diseases, as well as atherosclerosis, has been linked to AMD. Both histopathological and genetic investigations have underscored the immune system's role in AMD progression. The objective of this literature review was to summarize the actual knowledge, identify research gaps and to serve as a basis for future studies regarding the correlations between inflammation and AMD. We conducted a thorough search of the primary databases (Web of Science, Cochrane Library, PubMed/MEDLINE), using keywords such as 'age-related macular degeneration', 'inflammation', 'neurodegeneration', and 'C-reactive protein'. We included systematic reviews and meta-analyses that offer the most relevant results in this research area. We also included the results from recent studies that have not yet been widely approached. Our strategy also consisted of looking for relevant articles in the reference list.
视网膜是人体最脆弱的器官之一，对各种代谢紊乱、血管异常和炎症过程敏感。年龄相关性黄斑变性（AMD）影响着全球数百万人，是导致失明的一个重要原因。慢性炎症与包括帕金森病和阿尔茨海默病在内的多种退行性疾病以及动脉粥样硬化有关，也与AMD相关。组织病理学和遗传学研究均强调了免疫系统在AMD进展中的作用。这篇文献综述的目的是总结现有知识，找出研究空白，并为未来关于炎症与AMD之间相关性的研究提供基础。我们对主要数据库（科学网、考克兰图书馆、PubMed/MEDLINE）进行了全面检索，使用了“年龄相关性黄斑变性”“炎症”“神经退行性变”和“C反应蛋白”等关键词。我们纳入了该研究领域提供最相关结果的系统评价和荟萃分析。我们还纳入了尚未被广泛探讨的近期研究结果。我们的策略还包括在参考文献列表中查找相关文章。
