Cardiology Department, Beilinson, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
J Nucl Cardiol. 2013 Aug;20(4):539-44. doi: 10.1007/s12350-013-9730-2. Epub 2013 May 24.
We previously described the feasibility of performing myocardial perfusion imaging (MPI) with half the technetium (Tc-99m) activity using ordered-subset expectation maximization with resolution recovery (OSEM-RR) processing. This study sought to assess the accuracy of this technique by correlating the findings with coronary angiography.
Of 290 patients who underwent MPI-gated SPECT using a half dose of Tc-99m sestamibi and OSEM-RR software in 2010-2012 at a tertiary medical center, 62 were referred for invasive coronary angiography within 90 days and formed the study group. Ischemia was defined as a summed difference score (SDS) of >3 on the MPI scan. Luminal stenosis of ≥70% on invasive coronary angiography served as the reference.
Mean Tc-99m activity per study was 23.9 ± 11.5 mCi and mean effective radiation dose was 7.2 ± 3.4 mSv. MPI revealed no abnormalities in 10 patients (16.2%), myocardial infarction only in 8 patients (12.9%), and ischemia in 44 patients (71.1%). Overall sensitivity, specificity, and positive and negative predictive values for MPI compared to invasive angiography were 89.1%, 75.0%, 91.1%, and 70.5%, respectively.
MPI SPECT performed with a half dose of Tc-99m and OSEM-RR image processing correlates well with invasive angiography. (J Nucl Cardiol 2013).
我们之前描述了使用有序子集期望最大化与分辨率恢复（OSEM-RR）处理方法，用一半的锝（Tc-99m）活动进行心肌灌注成像（MPI）的可行性。本研究通过与冠状动脉造影相关，评估了该技术的准确性。
在 2010 年至 2012 年期间，在一家三级医疗中心，有 290 例患者接受了使用半剂量 Tc-99m sestamibi 和 OSEM-RR 软件的 MPI 门控 SPECT 检查，其中 62 例在 90 天内被转介进行侵入性冠状动脉造影，并形成研究组。MPI 扫描上的总和差异评分（SDS）>3 定义为缺血。侵入性冠状动脉造影上的管腔狭窄≥70%作为参考。
每例研究的 Tc-99m 平均活动量为 23.9±11.5 mCi，平均有效辐射剂量为 7.2±3.4 mSv。MPI 显示 10 例患者（16.2%）无异常，8 例患者（12.9%）仅显示心肌梗死，44 例患者（71.1%）显示缺血。MPI 与侵入性血管造影相比，整体敏感性、特异性、阳性预测值和阴性预测值分别为 89.1%、75.0%、91.1%和 70.5%。
使用一半剂量的 Tc-99m 和 OSEM-RR 图像处理进行 MPI SPECT 与侵入性血管造影相关性良好。（J Nucl Cardiol 2013）。
