Department of Cardiology, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
J Nucl Cardiol. 2012 Apr;19(2):303-10. doi: 10.1007/s12350-011-9498-1. Epub 2011 Dec 28.
To examine the yield of an ultra-low-dose computed tomography (CT) transmission module for attenuation-correction (AC) on a dedicated cardiac camera in evaluation of SPECT-myocardial perfusion imaging (MPI) in the diagnosis of CAD and for additional chest abnormalities.
The study group included 150 patients with known or suspected CAD referred for technetium sestamibi SPECT MPI. CT transmission scanning (effective radiation 0.17 mSv) was performed after each gated SPECT scan. AC and non-corrected (NC) SPECT scans were evaluated on a 5-point scale using a 17-segment model, and the sum stress score (SSS) and sum rest score (SRS) were calculated for each condition. Overall image quality, sensitivity and normalcy rate (51 patients) and processing of 28 CT slices were screened for chest findings.
CT-based AC significantly improved image quality (P = .01). Mean SSS was 3.8 ± 5.8 with AC and 6.1 ± 7.1 with NC (P < .001); the respective SRS values were 2.6 ± 6.3 and 3.9 ± 7.7 (P < .001). The sensitivity of detecting ≥70% stenosis was 71% and 86% (P = NS) and the normalcy rate was 30% and 89% (P < .0001) in NC and AC SPECT MPI, respectively. Chest CT: lung abnormalities in 31%, aortic calcifications in 27%, and hiatus hernia in 5%.
Ultra-low-dose CT for AC of SPECT-MPI improves image quality, diagnostic accuracy and suggests detection of chest findings.
检查超低压计算机断层扫描（CT）传输模块在专用心脏相机上衰减校正（AC）的产量，用于评估单光子发射计算机断层扫描（SPECT）心肌灌注成像（MPI）在 CAD 的诊断以及其他胸部异常。
研究组包括 150 名已知或疑似 CAD 的患者，他们因锝-99m sestamibi SPECT MPI 而接受检查。每次门控 SPECT 扫描后进行 CT 传输扫描（有效辐射 0.17 mSv）。使用 17 节段模型对 AC 和非校正（NC）SPECT 扫描进行 5 分制评估，并计算每种情况下的总和应激评分（SSS）和总和休息评分（SRS）。对整体图像质量、敏感性和正常率（51 例）进行筛选，并对 28 个 CT 切片进行处理，以发现胸部异常。
基于 CT 的 AC 显著提高了图像质量（P =.01）。AC 的平均 SSS 为 3.8 ± 5.8，NC 为 6.1 ± 7.1（P <.001）；相应的 SRS 值分别为 2.6 ± 6.3 和 3.9 ± 7.7（P <.001）。在 NC 和 AC SPECT MPI 中，检测 ≥70%狭窄的敏感性分别为 71%和 86%（P = NS），正常率分别为 30%和 89%（P <.0001）。胸部 CT：肺异常 31%，主动脉钙化 27%，膈疝 5%。
SPECT-MPI 的超低压 CT AC 可提高图像质量、诊断准确性，并提示发现胸部异常。
