Akhtar Kafil, Sen Ray Prasenjit, Ahmad S Shamhsad, Sherwani Rana K
Department of Pathology, Jawaharlal Nehru Medical College, AMU, Aligarh, Uttar Pradesh, India.
BMJ Case Rep. 2013 May 22;2013:bcr2013009518. doi: 10.1136/bcr-2013-009518.
Paraganglioma is a neuroendocrine tumour derived from extra-adrenal cells of the neural crest paraganglia of the autonomic nervous system. These rare neoplasms comprise of around 0.012% of head and neck tumours. Paraganglioma arising in the thyroid gland is exceptionally uncommon and can present as a diagnostic challenge on fine-needle aspiration cytology (FNAC). We report a case of primary thyroid paraganglioma in a 19-year-old woman who presented with a solitary thyroid nodule without palpable cervical lymphadenopathy. FNAC from the lesion caused diagnostic dilemma by mimicking follicular neoplasm and C-cell-derived thyroid tumours; final diagnosis was established by histopathology and immunohistochemistry. The main purpose of this case report is to discuss the differential diagnosis and emphasise on the need of immune markers in the diagnosis of thyroid paraganglioma. In view of the uncertain malignant potential of these tumours, a long-term follow-up is recommended.
副神经节瘤是一种神经内分泌肿瘤，起源于自主神经系统神经嵴副神经节的肾上腺外细胞。这些罕见肿瘤约占头颈部肿瘤的0.012%。发生于甲状腺的副神经节瘤极为罕见，在细针穿刺细胞学检查（FNAC）中可能构成诊断挑战。我们报告一例19岁女性原发性甲状腺副神经节瘤病例，该患者表现为孤立性甲状腺结节，无可触及的颈部淋巴结肿大。病变的FNAC因酷似滤泡性肿瘤和C细胞来源的甲状腺肿瘤而导致诊断困境；最终通过组织病理学和免疫组织化学确诊。本病例报告的主要目的是讨论鉴别诊断，并强调免疫标志物在甲状腺副神经节瘤诊断中的必要性。鉴于这些肿瘤的恶性潜能不确定，建议进行长期随访。
