Hodge K M, Byers R M, Peters L J
Department of Head and Neck Surgery, University of Texas, M.D. Anderson Hospital and Tumor Institute, Houston 77030.
Arch Otolaryngol Head Neck Surg. 1988 Aug;114(8):872-7. doi: 10.1001/archotol.1988.01860200056018.
The medical records of 64 patients with paraganglioma of the head and neck seen between 1954 and 1984 at the University of Texas M.D. Anderson Hospital, Houston, were reviewed. Lesions were found in the carotid body (n = 24), jugulotympanic area (n = 37), vagal nerve (n = 4), and larynx (n = 1). A hereditary pattern was identified in six patients (9%). Metastases developed and caused the death of two patients (8%). No functional secreting tumors were identified. Paragangliomas are often misdiagnosed, both clinically and pathologically. Angiography is the definitive clinical study for diagnosis and treatment planning. Computed tomographic scanning further defines extent of the disease. Lesions in the neck are effectively treated by surgery. Jugulotympanic tumors can be successfully managed by surgery, radiation therapy, or a combination of both depending on the size and extent of the tumor. Secondary treatment of residual disease can be as effective as primary treatment.
回顾了1954年至1984年间在休斯顿德克萨斯大学MD安德森医院就诊的64例头颈部副神经节瘤患者的病历。病变位于颈动脉体（n = 24）、颈鼓区（n = 37）、迷走神经（n = 4）和喉部（n = 1）。6例患者（9%）发现有遗传模式。发生转移并导致2例患者（8%）死亡。未发现功能性分泌肿瘤。副神经节瘤在临床和病理上常被误诊。血管造影是诊断和治疗计划的决定性临床检查。计算机断层扫描进一步明确疾病范围。颈部病变通过手术有效治疗。颈鼓区肿瘤可根据肿瘤大小和范围通过手术、放射治疗或两者联合成功治疗。残留疾病的二次治疗与初次治疗同样有效。
