用于宫颈癌筛查和宫颈疾病管理的基于人乳头瘤病毒（HPV）的检测
HPV-based Tests for Cervical Cancer Screening and Management of Cervical Disease.
作者信息
Luhn Patricia, Wentzensen Nicolas
机构信息
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD ; Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Rockville, MD.
出版信息
Curr Obstet Gynecol Rep. 2013 Jun 1;2(2):76-85. doi: 10.1007/s13669-013-0040-0.
Abstract
Current cervical cancer screening programs are changing due to the development of tests that detect the presence of human papillomavirus (HPV), the cause of cervical cancer. These tests are more sensitive than cytology-based methods for detecting cervical precancer and a negative test offers long-term assurance that cervical cancer will not develop and therefore longer screening intervals can be achieved. In screening programs, HPV-based tests have been approved to triage women with equivocal cytology results and as a primary testing method in conjunction with cytology. HPV-based tests also have a role in determining risk of recurrence after treatment for cervical precancer as well as in surveillance for vaccine-related changes in HPV genotype prevalence.
摘要
由于检测人乳头瘤病毒（HPV，宫颈癌病因）的检测方法的发展，当前的宫颈癌筛查项目正在发生变化。这些检测方法在检测宫颈上皮内瘤变方面比基于细胞学的方法更敏感，一次阴性检测可提供宫颈癌不会发生的长期保证，因此可以实现更长的筛查间隔。在筛查项目中，基于HPV的检测已被批准用于对细胞学结果不明确的女性进行分流，并作为与细胞学联合使用的主要检测方法。基于HPV的检测在确定宫颈上皮内瘤变治疗后的复发风险以及监测HPV基因型流行率与疫苗相关的变化方面也发挥着作用。
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本文引用的文献
1
Risk of high-grade cervical intraepithelial neoplasia during follow-up in HPV-positive women according to baseline p16-INK4A results: a prospective analysis of a nested substudy of the NTCC randomised controlled trial.根据基线 p16INK4A 结果，HPV 阳性女性随访中高级别宫颈上皮内瘤变的风险：一项嵌套于 NTCC 随机对照试验的前瞻性分析亚研究。
Lancet Oncol. 2013 Feb;14(2):168-76. doi: 10.1016/S1470-2045(12)70529-6. Epub 2012 Dec 21.
2
Evidence regarding human papillomavirus testing in secondary prevention of cervical cancer.有关人乳头瘤病毒检测在宫颈癌二级预防中的证据。
Vaccine. 2012 Nov 20;30 Suppl 5:F88-99. doi: 10.1016/j.vaccine.2012.06.095.
3
New technologies and procedures for cervical cancer screening.宫颈癌筛查的新技术和新程序。
Vaccine. 2012 Nov 20;30 Suppl 5:F107-16. doi: 10.1016/j.vaccine.2012.05.088.
4
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J Natl Cancer Inst. 2012 Nov 21;104(22):1738-49. doi: 10.1093/jnci/djs425. Epub 2012 Oct 23.
5
Human papillomavirus DNA methylation as a potential biomarker for cervical cancer.人乳头瘤病毒 DNA 甲基化作为宫颈癌的潜在生物标志物。
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6
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Lancet Infect Dis. 2012 Oct;12(10):781-9. doi: 10.1016/S1473-3099(12)70187-1. Epub 2012 Aug 22.
7
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8
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Ann Intern Med. 2012 Jun 19;156(12):880-91, W312. doi: 10.7326/0003-4819-156-12-201206190-00424.
9
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Int J Cancer. 2013 Jan 1;132(1):198-207. doi: 10.1002/ijc.27608. Epub 2012 Jun 20.
10
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Int J Cancer. 2013 Jan 1;132(1):148-54. doi: 10.1002/ijc.27577. Epub 2012 Apr 30.
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