暹罗鳄血液的体内外抗癌活性
[Anticancer activity of Crocodylus siamensis blood in vitro and in vivo].
作者信息
Geng Di, Duan Yu-Long, Xu Xiao-Lin, Wang Chun-Mei, Cui Xiao-Dong, Ouyang Zhao, Chen Bin
机构信息
Department of Biological Pharmaceutics, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
出版信息
Zhong Yao Cai. 2012 Dec;35(12):1901-4.
OBJECTIVE
To study the anticancer effects of the blood of Crocodylus siamensis in vitro and in vivo.
METHODS
The inhibitory effects of serum and plasma of Crocodylus siamensis on proliferation of HepG2, BGC823, HeLa and SKOV3 cell were measured by MTT assay. The mouse S180 tumor model was used to evaluate the anti-tumor effect in vivo.
RESULTS
High dosage serum and plasma of Crocodylus siamensis could inhibit the proliferation of HepG2, BGC823, HeLa and SKOV3 cell. The tumor inhibitory rate of high dosage blood of Crocodylus siamensis on S180 tumor was up to 57.55%.
CONCLUSION
The blood of breeding Crocodylus siamensis has anticancer activity.
目的
研究暹罗鳄血液在体内外的抗癌作用。
方法
采用MTT法检测暹罗鳄血清和血浆对人肝癌细胞HepG2、人胃癌细胞BGC823、人宫颈癌细胞HeLa和人卵巢癌细胞SKOV3增殖的抑制作用。利用小鼠S180肿瘤模型评价其体内抗肿瘤作用。
结果
高剂量暹罗鳄血清和血浆可抑制HepG2、BGC823、HeLa和SKOV3细胞的增殖。高剂量暹罗鳄血液对S180肿瘤的抑瘤率高达57.55%。
结论
养殖暹罗鳄的血液具有抗癌活性。
Zotero 插件