Sowers M F, Wallace R B
Department of Epidemiology, University of Michigan, Ann Arbor 48109.
J Clin Epidemiol. 1990;43(7):693-9. doi: 10.1016/0895-4356(90)90040-v.
Studies of hypervitaminosis A in animals and anecdotal reports of accidental vitamin A poisoning in humans suggest impairment of bone remodeling and increased numbers of fractures. Because of the widespread use of high-dose vitamin A supplements which may produce subclinical hypervitaminosis associated with decreased bone mass and increased risk of fracture, we studied the relationship between current vitamin A supplement use, serum retinol levels, radial bone mass and fracture history in a geographically-defined population of 246 postmenopausal women, 55-80 years of age. More than 36% of this population used a vitamin A supplement with 8% of these consuming an amount in excess of 2000 retinol equivalents (RE)/day. Serum retinol was measured using high-pressure liquid chromatography and radial bone mass was measured using single photon absorptiometry. After controlling for age, current estrogen replacement, and current thiazide antihypertensive use, we observed no statistically significant relationship between vitamin A supplement use or serum retinol with radial bone mass or fractures.
对动物维生素A过多症的研究以及关于人类意外维生素A中毒的轶事报道表明，骨重塑会受损且骨折数量会增加。由于高剂量维生素A补充剂的广泛使用，可能会产生与骨量减少和骨折风险增加相关的亚临床维生素A过多症，我们在一个地理区域限定的、年龄在55至80岁之间的246名绝经后女性人群中，研究了当前维生素A补充剂的使用、血清视黄醇水平、桡骨骨量与骨折史之间的关系。该人群中超过36%的人使用维生素A补充剂，其中8%的人每天摄入超过2000视黄醇当量（RE）。血清视黄醇采用高压液相色谱法测量，桡骨骨量采用单光子吸收法测量。在对年龄、当前雌激素替代疗法以及当前噻嗪类降压药的使用进行控制后，我们观察到维生素A补充剂的使用或血清视黄醇与桡骨骨量或骨折之间不存在统计学上的显著关系。
