Head and Neck Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Am J Otolaryngol. 2013 Sep-Oct;34(5):563-8. doi: 10.1016/j.amjoto.2013.04.007. Epub 2013 May 23.
The Ewing's sarcoma family of tumors is a group of cancers that commonly arises in young adults during their second decade of life. It frequently involves the trunk and long bones of the body with primary Ewing's sarcoma of the paranasal sinuses being exceedingly rare. We describe the case of a 39 year-old female with primary Ewing's Sarcoma originating from the ethmoid sinus with intracranial extension into the anterior cranial fossa and the orbit. The radiologic and histopathologic profiles are presented with a review of the literature. To our knowledge, this is the second reported case with the tumor involving the anterior cranial fossa, but the only case where immunochemical staining and molecular genetic analysis are available for definitive diagnosis.
尤文氏肉瘤家族肿瘤是一组常见于年轻人生命的第二个十年的癌症。它常发生于躯干和身体的长骨，而发生于鼻窦的原发性尤文氏肉瘤则极为罕见。我们描述了一例 39 岁女性，患有源自筛窦的原发性尤文氏肉瘤，肿瘤向颅前窝和眼眶内颅内扩展。本文呈现了其放射学和组织病理学特征，并进行了文献复习。据我们所知，这是第二例累及颅前窝的病例，但也是唯一一例可进行免疫化学染色和分子遗传学分析以明确诊断的病例。
