Department of Neuro-radiology, Cantonal Hospital Aarau, Aarau, Switzerland.
Ophthalmology. 2013 Oct;120(10):2125-9. doi: 10.1016/j.ophtha.2013.03.034. Epub 2013 May 21.
The aim of this study was to look for the response to strabismus images in the limbic network (amygdala, hippocampus, parahippocampus) of healthy volunteers and to compare it with their reaction to viewing normal eyes.
Prospective, observational study.
Thirty-one healthy volunteers underwent functional magnetic resonance imaging (fMRI).
Functional magnetic resonance imaging data and blood oxygen level-dependent signal changes were analyzed using the BrainVoyager QX software package (Brain Innovation, Maastricht, The Netherlands).
Responses to viewing strabismus images were compared with those observed while viewing normal eye images.
Strabismus images led to significant activation of the amygdala, hippocampus, parahippocampal, and fusiform gyri in 30 of 31 subjects compared with normal eye images, indicating a negative emotional response.
These fMRI results confirm that strabismus influences organically not only the patient with nonparallel eyes but also observers. Treatment of strabismus therefore changes the interpersonal dynamic for patients with strabismus on a demonstrable organic basis.
FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
本研究旨在寻找健康志愿者在边缘网络（杏仁核、海马体、海马旁回）中对斜视图像的反应，并将其与他们观看正常眼睛时的反应进行比较。
前瞻性、观察性研究。
31 名健康志愿者接受了功能磁共振成像（fMRI）检查。
使用 BrainVoyager QX 软件包（Brain Innovation，Maastricht，荷兰）分析功能磁共振成像数据和血氧水平依赖信号变化。
比较观看斜视图像与观看正常眼图像时的反应。
斜视图像与正常眼图像相比，在 31 名受试者中的 30 名中引起了杏仁核、海马体、海马旁回和梭状回的显著激活，表明存在负性情绪反应。
这些 fMRI 结果证实，斜视不仅对非平行眼的患者而且对观察者都具有器质性影响。因此，斜视治疗以可证明的器质性基础改变了斜视患者的人际动态。
作者没有任何与本文讨论的材料有关的专有或商业利益。
