Neuroradiology, Cantonal Hospital, Tellstrasse 25, 5001, Aarau, Switzerland.
Ophthalmology, Cantonal Hospital, Aarau, Switzerland.
Clin Neuroradiol. 2019 Mar;29(1):87-94. doi: 10.1007/s00062-017-0625-5. Epub 2017 Sep 14.
Strabismus influences not only the individual with nonparallel eyes but also the observer. It has previously been demonstrated by fMRI that adults viewing images of strabismic adults have a negative reaction to the images as demonstrated by limbic activation, especially activation of the left amygdala. The aim of this study was to see if mothers would have a similar reaction to viewing strabismic children and whether or not that reaction would be different in mothers of strabismic children.
Healthy mothers of children with strabismus (n = 10, Group I) and without strabismus (n = 15, Group II) voluntarily underwent fMRI at 3T. Blood oxygen level dependent signal responses to viewing images of strabismic and non-strabismic children were analyzed.
Group II, while viewing images of strabismic children, showed significantly increased activation of the limbic network (p < 0.05) and bilateral amygdala activation. Group I showed considerably less limbic activation, compared to the group II, and had no amygdala activation. Both groups revealed statically significant activation in the FEF (frontal eye field) when they were viewing images of strabismic children as compared to when they were viewing children with parallel eyes. The activated FEF area for Group II was much larger than for group I.
Mothers of non-strabismic children showed similar negative emotional fMRI patterns as adults did while viewing strabismic adults. Strabismus is an interpersonal organic issue for the observer, which also impacts the youngest members of our society.
斜视不仅会影响双眼不平行的个体，还会影响观察者。先前的 fMRI 研究表明，成年人观看斜视成年人的图像时，会产生负面反应，表现为边缘系统激活，尤其是左杏仁核激活。本研究旨在观察母亲是否会对斜视儿童的图像产生类似反应，以及斜视儿童的母亲是否会有不同反应。
10 名斜视儿童的健康母亲（I 组）和 15 名无斜视儿童的健康母亲（II 组）自愿在 3T 磁共振成像仪上进行 fMRI。分析了观看斜视和非斜视儿童图像时血氧水平依赖信号的反应。
与 II 组相比，I 组观看斜视儿童图像时，边缘网络（p<0.05）和双侧杏仁核激活明显增加。与 II 组相比，I 组的边缘激活明显减少，并且没有杏仁核激活。两组在观看斜视儿童的图像时，与观看双眼平行的儿童的图像相比，均显示出额叶眼区（FEF）的静息显著激活。与 I 组相比，II 组的 FEF 激活区域更大。
非斜视儿童的母亲在观看斜视成年人的图像时，表现出与成年人相似的负面情绪 fMRI 模式。斜视对视光者来说是一个人际的器质性问题，也会影响我们社会中最年轻的成员。
