Department of Internal Medicine, Graduate School, The Catholic University of Korea, Seoul, Republic of Korea.
Atherosclerosis. 2013 Jul;229(1):253-7. doi: 10.1016/j.atherosclerosis.2013.04.028. Epub 2013 May 6.
High serum phosphorus and the calcium-phosphorus product concentration has been associated with increased mortality and cardiovascular events in patients with chronic kidney disease.
This study was designed to determine the relationship between calcium-phosphorus product concentration and the presence of coronary artery calcification in subjects with metabolic syndrome (MetS).
We reviewed the medical records of 2056 general subjects with a mean age of 55.1 ± 9.9 years and a glomerular filtration rate of 88.9 ± 16.2 mL/min/1.73 m(2). The enrolled subjects consisted of 384 (18.7%) subjects with MetS and 1672 (81.3%) subjects without MetS. The severity of coronary artery calcification was assessed by the coronary artery calcification score (CACS) using multi-detector computed tomography (MDCT).
The CACS correlated with calcium-phosphorus product concentration in subjects with MetS (r = 0.184, P < 0.01). The odds ratio of calcium-phosphorus product concentration having CACS >50 was 1.053 in subjects with MetS (P < 0.05). After adjustment for age, sex, diabetes, and dyslipidemia, calcium-phosphorus product concentrations had a positive correlation with CACS in subjects with MetS. In single regression analysis, calcium-phosphorus product concentration as independent variable was the significant predictor of CACS in subjects with MetS. Using a multivariate analysis, calcium-phosphorus product concentration remained a significant factor associated with CACS in subjects with MetS.
Calcium-phosphorus product concentration was weakly associated with CACS and an independent factor predicting for CACS by MDCT in subjects with MetS. These results suggest that calcium-phosphorus product concentration might be considered as a risk factor of coronary artery disease in subjects with MetS.
高血清磷和钙磷乘积浓度与慢性肾脏病患者的死亡率和心血管事件增加有关。
本研究旨在确定钙磷乘积浓度与代谢综合征（MetS）患者冠状动脉钙化存在的关系。
我们回顾了 2056 名一般受试者的病历，平均年龄为 55.1 ± 9.9 岁，肾小球滤过率为 88.9 ± 16.2 mL/min/1.73 m²。纳入的受试者包括 384 名（18.7%）患有 MetS 的受试者和 1672 名（81.3%）无 MetS 的受试者。冠状动脉钙化的严重程度通过多排螺旋 CT（MDCT）的冠状动脉钙化评分（CACS）进行评估。
MetS 患者的 CACS 与钙磷乘积浓度相关（r = 0.184，P < 0.01）。MetS 患者钙磷乘积浓度 CACS >50 的比值比为 1.053（P < 0.05）。校正年龄、性别、糖尿病和血脂异常后，MetS 患者钙磷乘积浓度与 CACS 呈正相关。在单回归分析中，钙磷乘积浓度作为独立变量是 MetS 患者 CACS 的显著预测因子。在多变量分析中，钙磷乘积浓度仍然是 MetS 患者 CACS 的重要相关因素。
钙磷乘积浓度与 CACS 呈弱相关，是 MetS 患者 MDCT 预测 CACS 的独立因素。这些结果表明，钙磷乘积浓度可能被认为是 MetS 患者冠状动脉疾病的一个危险因素。
