Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Division for CVD Prevention and Control Network, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Chin Med J (Engl). 2013;126(24):4618-23.
Little is known about the influence of metabolic syndrome (MetS) on coronary artery calcification (CAC) in China. In this article, we aimed to explore the distribution of CAC in populations with and without MetS, and estimate the influence of MetS and its components on CAC in a community-based population of Beijing.
A total of 1647 local residents of Beijing, age 40-77 years, were recruited for a cardiovascular risk factors survey and were determined fasting plasma glucose (FPG), blood lipids, and 64 multi-detector computed tomography (64-MDCT) coronary artery calcium score (CACS) measurement (Agatston scoring). The distribution of CAC was described, and the influence of MetS components on CAC was evaluated.
In this population, the prevalence and extent of CAC increased with increasing age and both were higher in MetS subjects compared to nonMetS subjects (all P < 0.05), with the exception of those older than 65 years old. The risk of CAC increased with increasing numbers of MetS components, and the odds ratios for predicting positive CAC in subjects with 1, 2, 3, and = 4 MetS components were 1.60, 1.84, 2.12, and 3.12, respectively (all P < 0.05). Elevated blood pressure, elevated FPG, elevated triglycerides, and overweight increased the risk of CAC, yielding odds ratios of 2.64, 1.67, 1.32, and 1.37, respectively (all P < 0.05).
In the Beijing community-based population, MetS increases the risk of CAC. The risk of CAC increases with increasing numbers of MetS components. Not only the number, but also the variety of risk factors for MetS is correlated with the risk of CAC. Elevated blood pressure, hyperglycemia, hypertriglyceridemia and overweight increase the risk of CAC.
关于代谢综合征（MetS）对冠状动脉钙化（CAC）的影响，中国知之甚少。本文旨在探讨MetS 人群和非 MetS 人群 CAC 的分布情况，并评估 MetS 及其组分对北京社区人群 CAC 的影响。
共纳入北京当地 1647 名年龄 40-77 岁的居民，进行心血管危险因素调查，并检测空腹血糖（FPG）、血脂和 64 排多排螺旋 CT（64-MDCT）冠状动脉钙评分（CACS）（Agatston 评分）。描述 CAC 的分布情况，评估 MetS 组分对 CAC 的影响。
在该人群中，CAC 的患病率和严重程度随年龄的增长而增加，且 MetS 患者均高于非 MetS 患者（均 P<0.05），除外年龄>65 岁者。CAC 的风险随 MetS 组分数的增加而增加，在具有 1、2、3 和=4 个 MetS 组分的受试者中，预测 CAC 阳性的优势比分别为 1.60、1.84、2.12 和 3.12（均 P<0.05）。血压升高、FPG 升高、甘油三酯升高和超重增加 CAC 的风险，比值比分别为 2.64、1.67、1.32 和 1.37（均 P<0.05）。
在北京社区人群中，MetS 增加 CAC 的风险。CAC 的风险随 MetS 组分数量的增加而增加。不仅 MetS 的数量，而且 MetS 危险因素的种类与 CAC 的风险相关。血压升高、高血糖、高甘油三酯血症和超重增加 CAC 的风险。
