Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, KPK, Pakistan.
Eur J Pharmacol. 2013 Dec 5;721(1-3):391-4. doi: 10.1016/j.ejphar.2013.05.003. Epub 2013 May 21.
Peganum harmala (L) is a perennial plant which is native of eastern Iranian and west of India but also found in different regions of western USA. A number of β-carboline compounds with therapeutic importance and different pharmacological effects, are present in this plant. Among other alkaloids, such as, harmine, harmalol and vasicine, isolated from various parts of the plant, harmaline is considered as most valuable with reference to its medicinal importance. Harmaline has been extensively studied in last decade and known to exert multiple pharmacological effects including antileishmanial, antimicrobial, antiplatelet, antiplasmodial, antitumoral, hypothermic and vasorelaxant activity. The proposed work is intended to highlight the recent pharmacological aspects of β-carboline alkaloid "harmaline".
龙舌麻（Peganum harmala（L））是一种多年生植物，原产于伊朗东部和印度西部，但也分布于美国西部的不同地区。该植物中含有许多具有治疗作用和不同药理作用的β-咔啉化合物。在该植物的其他生物碱中，如从植物的不同部位分离出的哈尔明、哈尔醇和瓦西定等，哈尔碱被认为是最有价值的，因为它具有药用重要性。在过去十年中，哈尔碱得到了广泛的研究，已知具有多种药理作用，包括抗利什曼原虫、抗菌、抗血小板、抗疟原虫、抗肿瘤、解热和血管舒张活性。这项工作旨在强调β-咔啉生物碱“哈尔碱”的最新药理方面。
