Department of Obstetrics, Gynecology, and Neonatology, Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Am J Obstet Gynecol. 2013 Aug;209(2):106.e1-10. doi: 10.1016/j.ajog.2013.05.039. Epub 2013 May 23.
To offer a general figure of the available data on the relation between alcohol intake and risk of endometriosis, we conducted a systematic review and a metaanalysis of studies published up to May 2012.
We carried out a literature search of all case-control and cohort studies published as original articles in English up to May 2012. Only those papers that were published as full-length articles were considered. Pooled estimates of the relative risks (RRs) and the corresponding 95% confidence intervals (CIs) were calculated using fixed or, when significant heterogeneity among estimates emerged, random effects models. A total of 15 studies were identified for the review.
The summary estimate was 1.24 (95% CI, 1.12-1.36) for any alcohol intake vs no alcohol intake. Considering the results of the analyses of infrequent, moderate/regular, and heavy alcohol intake vs no alcohol intake, the summary RR estimates were, respectively, 1.14 (95% CI, 0.86-1.52), 1.23 (95% CI, 1.08-1.40), and 1.19 (95% CI, 0.99-1.43). Three studies reported separate results for current and former drinkers, and the summary RR were 1.42 (95% CI, 1.14-1.76) and 1.09 (95% CI, 0.83-1.43), respectively.
The present metaanalysis provides evidence for an association between alcohol consumption and endometriosis risk. Further studies are needed to clarify whether alcohol consumption may exacerbate an existing disease or could be related to the severity of the disease.
提供有关酒精摄入与子宫内膜异位症风险之间关系的现有数据的总体情况，我们对截至 2012 年 5 月发表的研究进行了系统评价和荟萃分析。
我们对截至 2012 年 5 月发表的所有以英文发表的病例对照和队列研究进行了文献检索。仅考虑作为全文发表的论文。使用固定或随机效应模型计算相对风险（RR）和相应的 95％置信区间（CI）的汇总估计值。共确定了 15 项综述研究。
任何饮酒与不饮酒相比的汇总估计值为 1.24（95％CI，1.12-1.36）。考虑到频繁，中度/规律和大量饮酒与不饮酒相比的分析结果，汇总 RR 估计值分别为 1.14（95％CI，0.86-1.52），1.23（95％CI，1.08-1.40）和 1.19（95％CI，0.99-1.43）。三项研究分别报告了当前和以前饮酒者的单独结果，汇总 RR 分别为 1.42（95％CI，1.14-1.76）和 1.09（95％CI，0.83-1.43）。
本荟萃分析为酒精摄入与子宫内膜异位症风险之间的关联提供了证据。需要进一步的研究来阐明饮酒是否可能加重现有疾病或与疾病的严重程度有关。
