神经内分泌系统中的永久性和塑性表型发生。

Permanent and plastic epigenesis in neuroendocrine systems.

机构信息

Neuroscience Training Program and Department of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA.

出版信息

Front Neuroendocrinol. 2013 Aug;34(3):190-7. doi: 10.1016/j.yfrne.2013.05.003. Epub 2013 May 23.

DOI:10.1016/j.yfrne.2013.05.003

Abstract

The emerging area of neuroepigenetics has been linked to numerous mental health illnesses. Importantly, a large portion of what we know about early gene×environment interactions comes from examining epigenetic modifications of neuroendocrine systems. This review will highlight how neuroepigenetic mechanisms during brain development program lasting differences in neuroendocrine systems and how other neuroepigenetic processes remain plastic, even within the adult brain. As epigenetic mechanisms can either be stable or plastic, elucidating the mechanisms involved in reversing these processes could aid in understanding how to reverse pathological epigenetic programming.

摘要

神经表观遗传学是一个新兴领域，与许多精神疾病有关。重要的是，我们对早期基因与环境相互作用的了解很大一部分来自于研究神经内分泌系统的表观遗传修饰。这篇综述将强调大脑发育过程中的神经表观遗传机制如何编程神经内分泌系统的持久差异，以及其他神经表观遗传过程如何保持可塑性，即使在成年大脑中也是如此。由于表观遗传机制要么稳定，要么具有可塑性，阐明逆转这些过程涉及的机制可能有助于理解如何逆转病理性表观遗传编程。