Department of Psychology, Columbia University, Room 406 Schermerhorn Hall, 1190 Amsterdam Avenue, New York, NY 10027, USA.
Clin Perinatol. 2011 Dec;38(4):703-17. doi: 10.1016/j.clp.2011.08.005.
Early-life adversity can affect brain development and behavior. Emerging evidence from studies on both humans and rodents suggests that epigenetic mechanisms may play a critical role in shaping our biology in response to the quality of the environment. This article highlights the research findings suggesting that prenatal maternal stress, postnatal maternal care, and infant neglect/abuse can lead to epigenetic variation, which may have long-term effects on stress responsivity, neuronal plasticity, and behavior.
早期生活逆境会影响大脑发育和行为。来自人类和啮齿动物研究的新证据表明，表观遗传机制可能在塑造我们的生物学对环境质量的反应方面发挥着关键作用。本文重点介绍了研究结果，表明产前母体应激、产后母婴护理和婴儿忽视/虐待会导致表观遗传变异，这可能对应激反应性、神经元可塑性和行为产生长期影响。
