The Department of Cardiology, St John Hospital and Medical Center, Detroit, MI, USA.
Am Heart J. 2013 Jun;165(6):893-901.e2. doi: 10.1016/j.ahj.2013.02.030. Epub 2013 Apr 9.
The aim of this study was to examine if racial disparities exist in the treatment and outcomes of patients undergoing contemporary percutaneous coronary intervention (PCI).
We examined the association between race, process of care, and outcomes of patients undergoing PCI between January 1, 2010, and December 31, 2011, and enrolled in the Blue Cross Blue Shield of Michigan Cardiovascular Consortium. We used propensity matching to compare the outcome of black and white patients.
The study cohort comprised 65,175 patients, of whom 6,873 (10.5%) were black and 55,789 (85.6%) were white. Black patients were more likely to be younger, be female, have more comorbidities, and be uninsured. Overall, black patients were less likely to receive prasugrel (10.0% vs 14.5%, P < .001) and drug-eluting stents (62.5% vs 67.7%, P < .001), largely related to lower use of these therapies in hospitals treating a higher proportion of black patients. No differences were seen between white and black patients with regard to inhospital mortality (odds ratio 1.34, 95% CI 0.82-2.2, P = .24), contrast-induced nephropathy (OR 1.06, 95% CI 0.81-1.40, P = .67), and need for transfusion (OR 1.27, 95% CI 0.98-1.64, P = .06). White race was associated with increased odds of heart failure (OR 1.48, 95% CI 1.05-2.08, P = .024) and vascular complications (OR 1.40, 95% CI 1.03-1.90, P = .032).
Compared with white patients, black patients undergoing PCI have a greater burden of comorbidities but, after adjusting for these differences, have similar inhospital survival and lower odds of vascular complications and heart failure after PCI.
本研究旨在探讨在接受当代经皮冠状动脉介入治疗(PCI)的患者中,种族差异是否存在于治疗和结局方面。
我们研究了 2010 年 1 月 1 日至 2011 年 12 月 31 日期间在密歇根蓝十字蓝盾心血管联合会注册并接受 PCI 的患者的种族、治疗过程与结局之间的关系。我们使用倾向匹配来比较黑人和白人患者的结局。
研究队列包括 65175 例患者,其中 6873 例(10.5%)为黑人,55789 例(85.6%)为白人。黑人患者更年轻、女性、合并症更多,且无保险。总体而言,黑人患者接受普拉格雷(10.0%比 14.5%,P<0.001)和药物洗脱支架(62.5%比 67.7%,P<0.001)的可能性较小,这主要与治疗更多黑人患者的医院中这些疗法的使用率较低有关。白人患者与黑人患者之间在院内死亡率(优势比 1.34,95%置信区间 0.82-2.2,P=0.24)、对比剂肾病(OR 1.06,95%置信区间 0.81-1.40,P=0.67)和输血需求(OR 1.27,95%置信区间 0.98-1.64,P=0.06)方面无差异。白人种族与心力衰竭(OR 1.48,95%置信区间 1.05-2.08,P=0.024)和血管并发症(OR 1.40,95%置信区间 1.03-1.90,P=0.032)的发生风险增加相关。
与白人患者相比,接受 PCI 的黑人患者合并症负担更重,但在调整这些差异后,其院内生存率相似,血管并发症和 PCI 后心力衰竭的发生风险较低。