Rutgers Robert Wood Johnson Medical School Piscataway NJ USA.
Department of Surgery Memorial Regional Hospital Hollywood FL USA.
J Am Heart Assoc. 2023 May 2;12(9):e026954. doi: 10.1161/JAHA.122.026954. Epub 2023 Apr 29.
Background In 1998, President Clinton launched a federal initiative to eliminate racial and ethnic health disparities. The impact on the outcomes of ST-segment-elevation myocardial infarction has not been well studied. Methods and Results ST-segment-elevation myocardial infarction outcomes from 1994 to 2015 were studied in 7942 Black, 27 665 Hispanic, and 88 727 White patients with first admission of ST-segment-elevation myocardial infarction using the Myocardial Infarction Data Acquisition System. Logistic regressions were used to assess mortality adjusting for demographics, comorbidities, and interventional procedures. There was an overall rise from 1994 to 2015 in the use of percutaneous coronary interventions in all 3 groups. Before 1998, White patients received more percutaneous coronary interventions compared with Black and Hispanic patients (<0.05). After 1998, the disparity in use of percutaneous coronary interventions in Black and Hispanic patients was greatly reduced compared with White patients, and the difference reversed in favor of Hispanic patients after 2005 (<0.05). There was an overall downward trend of in-hospital mortality without evidence of disparity among Black, Hispanic, and White patients. A linear regression model was used with a change point in 1998. Before 1998, the slope of 1-year all-cause and cardiovascular mortality was not statistically significant. After 1998, the mortality showed negative slopes for all 3 groups, however, with lower overall crude mortality for Hispanic patients compared with Black and White patients (<0.0001). Conclusions The initiative launched in 1998 may have contributed to a reduction in percutaneous coronary intervention usage disparity in patients with ST-segment-elevation myocardial infarction. Short- and long-term mortality decreased in all 3 groups, but more in the Hispanic population.
1998 年,克林顿总统发起了一项消除种族和民族健康差异的联邦倡议。但其对 ST 段抬高型心肌梗死(STEMI)结局的影响尚未得到充分研究。
使用心肌梗死数据采集系统,研究了 1994 年至 2015 年期间 7942 名黑人、27665 名西班牙裔和 88727 名白人首次因 STEMI 入院的患者的 STEMI 结局。采用逻辑回归模型,根据人口统计学、合并症和介入治疗调整死亡率。在所有 3 组中,1994 年至 2015 年期间,经皮冠状动脉介入治疗的使用率总体呈上升趋势。1998 年之前,与黑人和西班牙裔患者相比,白人患者接受更多的经皮冠状动脉介入治疗(<0.05)。1998 年之后,与白人患者相比,黑人和西班牙裔患者接受经皮冠状动脉介入治疗的差异大大缩小,并且在 2005 年之后,这一差异转为有利于西班牙裔患者(<0.05)。所有患者的院内死亡率呈总体下降趋势,且黑人、西班牙裔和白人患者之间没有差异。采用线性回归模型,以 1998 年为变化点。1998 年之前,1 年全因和心血管死亡率的斜率没有统计学意义。1998 年之后,所有 3 组的死亡率均呈负斜率,但西班牙裔患者的总体粗死亡率低于黑人和白人患者(<0.0001)。
1998 年发起的倡议可能有助于减少 STEMI 患者经皮冠状动脉介入治疗使用率的差异。所有 3 组的短期和长期死亡率均下降,但西班牙裔人群的死亡率降幅更大。