*Department of Clinical Education, Illinois Eye Institute, Illinois College of Optometry and Departments of †Epidemiology and Biostatistics ‡Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL.
J Glaucoma. 2014 Sep;23(7):441-5. doi: 10.1097/IJG.0b013e3182946522.
To investigate presence of remnants of the tunica vasculosa lentis, a possible indication of anterior segment dysgenesis, in subjects with the long anterior zonule (LAZ) trait.
Retroillumination photographs of the pupil region had been collected in earlier study of the LAZ trait in African Americans. Secondary image analysis was performed to assess the frequency of intact persistent pupillary membrane iris strands (PPMIS).
The analysis included 148 subjects, comprised of 74 LAZ subjects (median age=70 y; range, 50 to 91 y; 64 females) and 74 controls (68 y; 50 to 83 y; 64 females). While controlling for age and sex, analysis showed that LAZ subjects were 3.1 times more likely than controls (odds ratio=3.1; 95% confidence interval, 1.4-6.7; P=0.004) to exhibit PPMIS in at least one of their eyes.
The LAZ trait, which is being studied as a potential risk factor for glaucoma, was associated with presence of PPMIS in our study population.
研究具有长前悬韧带(LAZ)特征的受试者中,存在脉络膜血管膜残余物(可能是前节发育不良的迹象)的情况。
在对非裔美国人的 LAZ 特征进行的早期研究中,已经收集了瞳孔区域的背反射照片。进行了二次图像分析,以评估完整的持续性瞳孔膜虹膜索(PPMIS)的频率。
分析包括 148 名受试者,其中 74 名 LAZ 受试者(中位数年龄为 70 岁;范围为 50 岁至 91 岁;64 名女性)和 74 名对照者(68 岁;50 岁至 83 岁;64 名女性)。在控制年龄和性别后,分析表明,与对照组相比,LAZ 受试者出现至少一眼 PPMIS 的可能性高 3.1 倍(优势比=3.1;95%置信区间,1.4-6.7;P=0.004)。
在本研究人群中,作为青光眼潜在危险因素之一的 LAZ 特征与 PPMIS 的存在有关。