Illinois Eye Institute, Illinois College of Optometry, Department of Clinical Education, Chicago, Illinois, United States.
University of Illinois at Chicago, School of Medicine, Department of Ophthalmology and Visual Sciences, Chicago, Illinois, United States.
Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):2015-2023. doi: 10.1167/iovs.17-23705.
To investigate the relation between intraocular pressure (IOP) and the idiopathic long anterior zonule (LAZ) trait.
Patients presenting for primary eye care were examined for LAZ, identified as radially oriented zonular fibers with central extension >1.0 mm beyond the normal anterior lens insertion zone (estimated via slit lamp beam length). Ocular, systemic health, and lifestyle data were collected via comprehensive exam and questionnaire. Multivariate regression was used to assess the relationship between IOP (Goldmann) and LAZ.
There were 2169 non-LAZ and 129 LAZ subjects (mean age: 49.8 ± 15.0 vs. 62.6 ± 10.2 years; 63.6% vs. 76.0% female; 83.2% vs. 91.5% African American). Right eyes with >trace LAZ (n = 59 of 110) had higher unadjusted mean IOP than control eyes (16.4 ± 3.3 vs. 15.0 ± 3.3 mm Hg, P = 0.005), and with control for numerous factors, LAZ eyes had an average IOP of approximately 1.3 ± 0.4 mm Hg higher (P = 0.003) than non-LAZ eyes. Final model covariates included sex (P = 0.001); spherical-equivalent refractive error (D; P < 0.0001); body mass index (kg/m2; P < 0.001); presence of diabetes (P < 0.001); having >high school education (P < 0.001); systolic blood pressure (mm Hg; P < 0.0001); being an ever smoker (P = 0.006); and having history of any site cancer (P = 0.01).
The LAZ trait, with potential prevalence near 2%, was associated with a higher IOP. This observation is consistent with the hypothesis that the trait is a marker for underlying mechanisms that elevate glaucoma risk.
研究眼内压（IOP）与特发性长前悬韧带（LAZ）特征之间的关系。
对因原发性眼病就诊的患者进行 LAZ 检查，LAZ 被定义为具有中央延伸超过正常前晶状体插入区 1.0mm 以上的放射状排列的悬韧带纤维（通过裂隙灯光束长度估计）。通过全面检查和问卷调查收集眼部、全身健康和生活方式数据。多变量回归用于评估 IOP（Goldmann）与 LAZ 之间的关系。
共有 2169 名非 LAZ 患者和 129 名 LAZ 患者（平均年龄：49.8 ± 15.0 岁 vs. 62.6 ± 10.2 岁；女性占 63.6% vs. 76.0%；83.2% vs. 91.5%为非裔美国人）。右眼有>微量 LAZ（n = 110 中的 59 例）的未校正平均IOP 高于对照眼（16.4 ± 3.3 vs. 15.0 ± 3.3mmHg，P = 0.005），控制多个因素后，LAZ 眼的平均 IOP 约高 1.3 ± 0.4mmHg（P = 0.003）比非 LAZ 眼。最终模型协变量包括性别（P = 0.001）；等效球镜屈光误差（D；P < 0.0001）；体重指数（kg/m2；P < 0.001）；糖尿病存在（P < 0.001）；受过高中以上教育（P < 0.001）；收缩压（mmHg；P < 0.0001）；曾吸烟者（P = 0.006）；有任何部位癌症史（P = 0.01）。
LAZ 特征的患病率接近 2%，与较高的 IOP 相关。这一观察结果与假设一致，即该特征是潜在机制升高青光眼风险的标志物。
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