The ubiquitin ligase Siah2 is revealed as an accomplice of the androgen receptor in castration resistant prostate cancer.
作者信息
Freeman Michael R
机构信息
Research Division of Cancer Biology and Therapeutics, Department of Surgery, Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA 90048, USA.
出版信息
Asian J Androl. 2013 Jul;15(4):447-8. doi: 10.1038/aja.2013.62. Epub 2013 May 27.
Abstract
摘要
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本文引用的文献
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The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity.
Cancer Cell. 2013 Mar 18;23(3):332-46. doi: 10.1016/j.ccr.2013.02.016.
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The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man.
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The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process.
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Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors.
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