巴基斯坦卡拉奇饮用水供应中自由生活阿米巴（棘阿米巴属 spp.、福氏耐格里阿米巴、狒狒巴拉姆希阿米巴）的状况。
Status of free-living amoebae (Acanthamoeba spp., Naegleria fowleri, Balamuthia mandrillaris) in drinking water supplies in Karachi, Pakistan.
机构信息
Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
出版信息
J Water Health. 2013 Jun;11(2):371-5. doi: 10.2166/wh.2013.112.
The ability of pathogenic free-living amoebae to produce infections is a growing concern. In this study, we investigated the presence of free-living amoebae (Acanthamoeba spp., Naegleria fowleri, Balamuthia mandrillaris) in drinking water supplies in Karachi, Pakistan. Fifty-two domestic tap water samples were examined. Amoebae were identified by morphological characteristics and polymerase chain reaction. Thirty percent of the examined samples were positive for Acanthamoeba spp., 8% for N. fowleri while B. mandrillaris were not recovered. Additionally we examined secretory IgA antibody to Acanthamoeba and B. mandrillaris. Acanthamoeba antibody prevalence rate was 100% in both males and females, while B. mandrillaris antibody prevalence rate was 5.5% in males only (females were negative). Our findings suggest that free-living amoebae are a potential health hazard in domestic water supplies in Karachi, Pakistan.
致病自由生活阿米巴能够引起感染，这引起了越来越多的关注。在这项研究中，我们调查了巴基斯坦卡拉奇饮用水供应中自由生活阿米巴（棘阿米巴属、福氏耐格里阿米巴、狒狒巴拉姆希阿米巴）的存在情况。检查了 52 份家庭自来水样本。通过形态特征和聚合酶链反应鉴定阿米巴。检查的样本中有 30%呈棘阿米巴阳性，8%呈福氏耐格里阿米巴阳性，而未检出狒狒巴拉姆希阿米巴。此外，我们还检查了针对棘阿米巴和狒狒巴拉姆希阿米巴的分泌型免疫球蛋白 A 抗体。在男性和女性中，棘阿米巴抗体的流行率均为 100%，而在男性中，狒狒巴拉姆希阿米巴抗体的流行率仅为 5.5%（女性均为阴性）。我们的研究结果表明，自由生活阿米巴是巴基斯坦卡拉奇家庭供水系统中的一个潜在健康危害。
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