血清尿激酶对尿液纤溶活性的影响。

Effect of serum urokinase on urine fibrinolytic activity.

作者信息

Hong S Y, Pyo S J, Lee H B

机构信息

Department of Internal Medicine, Soonchunghyang University Hospital, Chunan City, Chungnam, South Korea.

出版信息

Nephron. 1990;55(3):287-91. doi: 10.1159/000185977.

DOI:10.1159/000185977

PMID:2370929

Abstract

The purpose of this study was to see if the serum level of urokinase might influence the urine fibrinolytic activity. Serum fibrinolytic activity precipitated in dextran sulfate euglobulin fraction was measured on the plasminogen-rich plate before, during, and after the urokinase infusion. The fibrinolytic activity of euglobulin increased during urokinase infusion by dose-dependent pattern (n = 4, mean: 230%, range: 173-333% of basal level) and decreased below the basal level after cessation of urokinase (n = 4, mean: 18%, range: 0-27% of basal level). There was inverse correlation between the urine fibrinolytic activity and serum fibrinolytic activity in all cases (r = -0.75, 0.01 less than p less than 0.02 in case 2; r = -0.88, 0.0001 less than p less than 0.005 in case 3; r = -0.74, 0.05 less than p less than 0.10 in case 1a and r = 0.59, 0.05 less than p less than 0.10 in case 1b). This finding suggests that the urine fibrinolytic activity production was under control of the serum urokinase level with feedback mechanism.

摘要

本研究的目的是观察尿激酶的血清水平是否会影响尿液纤溶活性。在输注尿激酶之前、期间和之后，在富含纤溶酶原的平板上测量硫酸葡聚糖优球蛋白组分中沉淀的血清纤溶活性。优球蛋白的纤溶活性在尿激酶输注期间呈剂量依赖性增加（n = 4，平均值：230%，范围：基础水平的173 - 333%），尿激酶停止输注后降至基础水平以下（n = 4，平均值：18%，范围：基础水平的0 - 27%）。在所有病例中，尿液纤溶活性与血清纤溶活性之间均呈负相关（病例2中r = -0.75，0.01 < p < 0.02；病例3中r = -0.88，0.0001 < p < 0.005；病例1a中r = -0.74，0.05 < p < 0.10；病例1b中r = 0.59，0.05 < p < 0.10）。这一发现表明，尿液纤溶活性的产生受血清尿激酶水平的反馈机制控制。