血管活性肠肽（VIP）刺激大鼠的纤溶系统。
Vasoactive intestinal polypeptide (VIP) stimulates fibrinolytic system in the rat.
作者信息
Hagiwara M, Hongo K, Morikawa T
机构信息
Fuji Chemical Industries, Ltd., Toyama Japan.
出版信息
Jpn J Pharmacol. 1990 Sep;54(1):86-8. doi: 10.1254/jjp.54.86.
We have studied the fibrinolytic effect of VIP in rats. Intravenous injection of VIP enhanced blood fibrinolytic activity in a dose-related manner. The euglobulin fraction obtained from intact rat plasma incubated with VIP did not produce an increase in fibrinolytic activity, while dextran sulfate (DS) and urokinase (UK) showed the activity. VIP solution placed on a plasminogen-rich fibrin plate did not show fibrinolysis. VIP had neither a plasminogen activator nor plasmin activity. VIP may release plasminogen activators into the blood.
我们研究了血管活性肠肽（VIP）对大鼠的纤溶作用。静脉注射VIP可使血液纤溶活性呈剂量依赖性增强。从与VIP孵育的完整大鼠血浆中获得的优球蛋白部分未使纤溶活性增加，而硫酸葡聚糖（DS）和尿激酶（UK）则显示出活性。置于富含纤溶酶原的纤维蛋白平板上的VIP溶液未显示出纤维蛋白溶解现象。VIP既没有纤溶酶原激活剂活性也没有纤溶酶活性。VIP可能会将纤溶酶原激活剂释放到血液中。
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