Di Antonio Luca, Toto Lisa, Carpineto Paolo, Mastropasqua Alessandra, De Nicola Chiara, Mastropasqua Leonardo
Department of Medicine and Science of Ageing, Ophthalmology Clinic, University "G. d'Annunzio" Chieti-Pescara - Italy.
Eur J Ophthalmol. 2014 Jan-Feb;24(1):134-7. doi: 10.5301/ejo.5000317. Epub 2013 May 20.
To report a case of macular pseudohole (MPH) development after sustained-release dexamethasone intravitreal implant for chronic macular edema due to central retinal vein occlusion (CRVO).
A 70-year-old man with cystoid macular edema (CME) due to CRVO underwent sustained-release dexamethasone intravitreal implant. En face optical coherence tomography (OCT) was performed before and after treatment.
One month after dexamethasone intravitreal implant, best-corrected visual acuity (BCVA) improved from 1.0 to 0.5 logMAR. At 2 months, BCVA decreased from 0.5 to 1.3 logMAR. En face OCT detected the development of MPH due to exacerbation of centripetal vitreomacular transverse tractional forces on the overlying retina.
Macular pseudohole seems to be a complication of intravitreal therapy in patients with coexisting vitreomacular traction. En face OCT gives useful information to understand the mechanism of MPH development after sustained-release dexamethasone intravitreal implant.
报告1例因视网膜中央静脉阻塞（CRVO）导致的慢性黄斑水肿患者在玻璃体内植入地塞米松缓释剂后发生黄斑假性裂孔（MPH）的病例。
1例因CRVO导致黄斑囊样水肿（CME）的70岁男性患者接受了玻璃体内地塞米松缓释剂植入术。在治疗前后进行了正面光学相干断层扫描（OCT）。
玻璃体内植入地塞米松1个月后，最佳矫正视力（BCVA）从1.0提高到0.5 logMAR。2个月时，BCVA从0.5下降到1.3 logMAR。正面OCT检测到由于覆盖视网膜上向心性玻璃体黄斑横向牵拉力加剧导致MPH形成。
黄斑假性裂孔似乎是存在玻璃体黄斑牵拉的患者玻璃体腔内治疗的一种并发症。正面OCT为理解玻璃体内植入地塞米松缓释剂后MPH形成的机制提供了有用信息。
