缺氧诱导因子在髓核细胞生物学行为中的调控作用。
Regulatory role of hypoxia inducible factor in the biological behavior of nucleus pulposus cells.
机构信息
Department of Orthopedics Surgery, The Second Hospital of Medical College, Zhejiang University, Jie fang Road 88#, Hangzhou 310009, China.
出版信息
Yonsei Med J. 2013 Jul;54(4):807-12. doi: 10.3349/ymj.2013.54.4.807.
Abstract
Intervertebral disc (IVD) degeneration is implicated as a major cause of low back pain. The alternated phenotypes, reduced cell survival, decreased metabolic activity, loss of matrix production and dystrophic mineralization of nucleus pulposus (NP) cells may be key contributors to progressive IVD degeneration. IVD is the largest avascular structure in the body, characterized by low oxygen tension in vivo. Hypoxia-inducible factor (HIF) is a master transcription factor that is induced upon hypoxia and directs coordinated cellular responses to hypoxic environments. This review summarizes relevant studies concerning the involvement of HIF in the regulation of biological behaviors of NP cells. We describe current data on the expression of HIF in NP cells and further discuss the various roles that HIF plays in the regulation of the phenotype, survival, metabolism, matrix production and dystrophic mineralization of NP cells. Here, we conclude that HIF may be a promising target for the prevention and treatment of IVD degeneration.
摘要
椎间盘（IVD）退变被认为是腰痛的主要原因。 髓核（NP）细胞表型改变、细胞存活率降低、代谢活性降低、基质产生减少和营养不良性矿化可能是 IVD 进行性退变的关键因素。IVD 是人体中最大的无血管结构，其特点是体内氧分压低。缺氧诱导因子（HIF）是一种主要的转录因子，在缺氧时被诱导，并指导细胞对缺氧环境的协调反应。 本综述总结了 HIF 参与调节 NP 细胞生物学行为的相关研究。 我们描述了 NP 细胞中 HIF 的表达情况，并进一步讨论了 HIF 在调节 NP 细胞表型、存活、代谢、基质产生和营养不良性矿化中的各种作用。 综上所述，HIF 可能是预防和治疗 IVD 退变的有希望的靶点。
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