Dou Yiming, Sun Xun, Ma Xinlong, Zhao Xin, Yang Qiang
Department of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, China.
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Front Bioeng Biotechnol. 2021 Jul 20;9:592118. doi: 10.3389/fbioe.2021.592118. eCollection 2021.
Intervertebral disk degeneration (IVDD) is a leading cause of disability. The degeneration is inevitable, and the mechanisms are complex. Current therapeutic strategies mainly focus on the relief of symptoms, not the intrinsic regeneration of the intervertebral disk (IVD). Tissue engineering is a promising strategy for IVDD due to its ability to restore a healthy microenvironment and promote IVD regeneration. This review briefly summarizes the IVD anatomy and composition and then sets out elements of the microenvironment and the interactions. We rationalized different scaffolds based on tissue engineering strategies used recently. To fulfill the complete restoration of a healthy IVD microenvironment, we propose that various tissue engineering strategies should be combined and customized to create personalized therapeutic strategies for each individual.
椎间盘退变（IVDD）是导致残疾的主要原因。这种退变是不可避免的，其机制也很复杂。目前的治疗策略主要集中在缓解症状上，而非椎间盘（IVD）的内在再生。组织工程因其能够恢复健康的微环境并促进IVD再生，是一种有前景的IVDD治疗策略。本综述简要总结了IVD的解剖结构和组成，然后阐述了微环境的要素及其相互作用。我们基于最近使用的组织工程策略对不同的支架进行了合理化分析。为了实现对健康IVD微环境的完全恢复，我们建议应将各种组织工程策略结合起来并进行定制，为每个个体制定个性化的治疗策略。
