Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10 Street, 10-747 Olsztyn, Poland.
Int J Endocrinol. 2013;2013:650984. doi: 10.1155/2013/650984. Epub 2013 Apr 23.
Phytoestrogens, polyphenolic compounds derived from plants, are more and more common constituents of human and animal diets. In most of the cases, these chemicals are much less potent than endogenous estrogens but exert their biological effects via similar mechanisms of action. The most common source of phytoestrogen exposure to humans as well as ruminants is soybean-derived foods that are rich in the isoflavones genistein and daidzein being metabolized in the digestive tract to even more potent metabolites-para-ethyl-phenol and equol. Phytoestrogens have recently come into considerable interest due to the increasing information on their adverse effects in human and animal reproduction, increasing the number of people substituting animal proteins with plant-derived proteins. Finally, the soybean becomes the main source of protein in animal fodder because of an absolute prohibition of bone meal use for animal feeding in 1995 in Europe. The review describes how exposure of soybean-derived phytoestrogens can have adverse effects on reproductive performance in female adults.
植物雌激素是从植物中提取的多酚化合物，越来越多地成为人类和动物饮食的组成部分。在大多数情况下，这些化学物质的效力远不及内源性雌激素，但它们通过类似的作用机制发挥生物效应。人类和反刍动物摄入植物雌激素的最常见来源是富含异黄酮染料木黄酮和大豆苷元的大豆衍生食品，这些物质在消化道中代谢为更有效的代谢物——对乙基苯酚和雌马酚。由于越来越多的信息表明植物雌激素对人类和动物生殖有不良影响，越来越多的人用植物蛋白替代动物蛋白，因此植物雌激素最近引起了相当大的关注。最后，由于 1995 年在欧洲绝对禁止使用骨粉作为动物饲料，大豆成为动物饲料的主要蛋白质来源。本文综述了大豆衍生植物雌激素的暴露如何对成年雌性动物的生殖性能产生不良影响。
