Endocrinology and Metabolism Department of the Second Hospital Affiliated to Harbin Medical University, Harbin Medical University, Harbin, Heilongjiang Province 150086, China.
Int J Endocrinol. 2013;2013:821403. doi: 10.1155/2013/821403. Epub 2013 Apr 23.
Objective. To compare clinical characteristics, immunological markers, and β -cell functions of 4 subgroups ("A β " classification system) of ketosis-onset diabetes and ketosis prone diabetes patients without known diabetes, presenting with ketosis or diabetic ketoacidosis (DKA) and admitted to our department from March 2011 to December 2011 in China, with 50 healthy persons as control group. Results. β -cell functional reserve was preserved in 63.52% of patients. In almost each subgroup (except A- β - subgroup of ketosis prone group), male patients were more than female ones. The age of the majority of patients in ketosis prone group was older than that of ketosis-onset group, except A- β - subgroup of ketosis prone group. The durations from the patient first time ketosis or DKA onset to admitting to the hospital have significant difference, which were much longer for the ketosis prone group except the A+ β + subgroup. BMI has no significant difference among subgroups. FPG of ketosis prone group was lower than that of A- β + subgroup and A+ β + subgroup in ketosis-onset group. A- β - subgroup and A+ β + subgroup of ketosis prone group have lower HbA1c than ketosis-onset group. Conclusions. Ketosis-onset diabetes and ketosis prone diabetes do not absolutely have the same clinical characteristics. Each subgroup shows different specialty.
目的。比较中国 2011 年 3 月至 12 月期间因酮症或糖尿病酮症酸中毒（DKA）入院，且无已知糖尿病史的酮症起病糖尿病和易发生酮症糖尿病患者的临床特征、免疫标志物和β细胞功能，这些患者可分为 4 个亚组（“A β ”分类系统），并与 50 名健康人作为对照组。结果。β细胞功能储备在 63.52%的患者中得到保留。在几乎每个亚组（易发生酮症组的 A- β -亚组除外）中，男性患者均多于女性患者。易发生酮症组的大多数患者年龄大于酮症起病组，除易发生酮症组的 A- β -亚组外。易发生酮症组患者从首次出现酮症或 DKA 到入院的时间明显长于酮症起病组，除 A+β+亚组外。BMI 在各亚组之间无显著差异。易发生酮症组的 FPG 低于酮症起病组的 A- β +亚组和 A+β+亚组。易发生酮症组的 A- β -亚组和 A+β+亚组的 HbA1c 低于酮症起病组。结论。酮症起病糖尿病和易发生酮症糖尿病并非完全具有相同的临床特征。每个亚组都表现出不同的特点。
