Department of Endocrinology and Diabetology, La Rabta Hospital, Tunis, Tunisia.
East Mediterr Health J. 2010 Jan;16(1):70-4.
The aim of this study in Tunisia was to classify ketosis-onset diabetes in adult patients. All patients aged > 30 years without known diabetes, presenting with ketosis and admitted to our department were studied. Patients with secondary or gestational diabetes and those on corticoid therapy or with coinciding infection were excluded. The data included clinical characteristics, immunological markers and beta-cell function. Of the 63 patients, islet-cell antibodies were present in 27.0%, glutamic acid decarboxylase antibodies in 25.4% and thyrosin phosphatase antibodies in 19.0%. Beta-cell functional reserve was preserved in 54.0%. Our results confirm that patients with ketosis-onset diabetes mellitus in adulthood are a heterogeneous group.
本研究旨在对突尼斯的成年发病酮症倾向糖尿病患者进行分类。所有年龄>30 岁、无已知糖尿病、以酮症起病并收入我科的患者均纳入研究。排除患有继发性或妊娠期糖尿病、正在接受皮质激素治疗或合并感染的患者。本研究的数据包括临床特征、免疫标志物和胰岛细胞功能。在 63 例患者中，胰岛细胞抗体阳性率为 27.0%，谷氨酸脱羧酶抗体阳性率为 25.4%，酪氨酸磷酸酶抗体阳性率为 19.0%。54.0%的患者β细胞功能储备正常。我们的研究结果证实，成年发病酮症倾向糖尿病患者是一组异质性群体。
