Department of Thoracic Medicine, University Hospital of Heraklion, Crete, Greece.
Clin Exp Rheumatol. 2013 Jul-Aug;31(4):610-1. Epub 2013 May 27.
To explore the SDF-1/ CXCR4 axis as driving mechanism of bone marrow mesenchymal stem-cells to the injured lung in patients with rheumatoid arthritis associated usual interstitial pneumonia (RA-UIP).
We evaluated the m-RNA expression of SDF-1 and CXCR4 with real-time PCR in bone marrow mesenchymal stem cells of 7 RA-UIP and 10 RA patients without lung involvement.
The axis was not expressed in RA whereas both SDF-1 and CXCR4 were expressed in RA-UIP [1.93 (1.32, 2.00) and 0.008 (0, 0.01)] respectively.
The development of pulmonary fibrosis in RA may be considered as the key event for the migration of stem cells to the injured lung through the SDF-1/CXCR4 axis.
探讨 SDF-1/CXCR4 轴作为类风湿关节炎相关寻常型间质性肺炎（RA-UIP）患者骨髓间充质干细胞向损伤肺部迁移的驱动机制。
我们采用实时 PCR 法检测了 7 例 RA-UIP 患者和 10 例无肺部受累的 RA 患者骨髓间充质干细胞中 SDF-1 和 CXCR4 的 m-RNA 表达。
RA 患者中未表达该轴，而 RA-UIP 患者中 SDF-1 和 CXCR4 均有表达[分别为 1.93（1.32，2.00）和 0.008（0，0.01）]。
RA 患者肺部纤维化的发展可被视为通过 SDF-1/CXCR4 轴将干细胞迁移至损伤肺部的关键事件。
