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衰老大鼠对呼吸机诱导的肺损伤的易感性增加。

Susceptibility to ventilator induced lung injury is increased in senescent rats.

作者信息

Setzer Florian, Oschatz Karsten, Hueter Lars, Schmidt Barbara, Schwarzkopf Konrad, Schreiber Torsten

出版信息

Crit Care. 2013 May 27;17(3):R99. doi: 10.1186/cc12744.

DOI:10.1186/cc12744
PMID:23710684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4056597/
Abstract

INTRODUCTION

The principal mechanisms of ventilator induced lung injury (VILI) have been investigated in numerous animal studies. However, prospective data on the effect of old age on VILI are limited. Under the hypothesis that susceptibility to VILI is increased in old age, we investigated the pulmonary and extrapulmonary effects of mechanical ventilation with high tidal volume (VT) in old compared to young adult animals.

INTERVENTIONS

Old (19.1±3.0 months) and young adult (4.4±1.3 months) male Wistar rats were anesthetized and mechanically ventilated (positive end-expiratory pressure 5 cmH2O, fraction of inspired oxygen 0.4, respiratory rate 40/minute) with a tidal volume (VT) of either 8, 16 or 24 ml/kg for four hours.

RESULTS

Compared to young adult animals, high VT (24 ml/kg body weight) caused more lung injury in old animals as indicated by decreased oxygenation (arterial oxygen tension (PaO2): 208±3 vs. 131±20 mmHg; P<0.05), increased lung wet-to-dry-weight ratio (5.61±0.29 vs. 7.52±0.27; P<0.05), lung lavage protein (206±52 mg/l vs. 1,432±101; P<0.05) and cytokine (IL-6: 856±448 vs. 3,283±943 pg/ml; P<0.05) concentration. In addition, old animals ventilated with high VT had more systemic inflammation than young animals (IL-1β: 149±44 vs. 272±36 pg/ml; P<0.05--young vs. old, respectively).

CONCLUSIONS

Ventilation with unphysiologically large tidal volumes is associated with more lung injury in old compared to young rats. Aggravated pulmonary and systemic inflammation is a key finding in old animals developing VILI.

摘要

引言

众多动物研究已对呼吸机诱导性肺损伤（VILI）的主要机制进行了探究。然而，关于老年对VILI影响的前瞻性数据有限。基于老年个体对VILI易感性增加的假设，我们研究了与年轻成年动物相比，大潮气量（VT）机械通气对老年动物肺部和肺外的影响。

干预措施

将老年（19.1±3.0个月）和年轻成年（4.4±1.3个月）雄性Wistar大鼠麻醉，并分别给予8、16或24ml/kg的潮气量进行机械通气（呼气末正压5cmH₂O，吸入氧分数0.4，呼吸频率40次/分钟），持续4小时。

结果

与年轻成年动物相比，大潮气量（24ml/kg体重）导致老年动物出现更多肺损伤，表现为氧合降低（动脉血氧分压（PaO₂）：208±3 vs. 131±20mmHg；P<0.05）、肺湿干重比增加（5.61±0.29 vs. 7.52±0.27；P<0.05）、肺灌洗蛋白（206±52mg/l vs. 1432±101；P<0.05）和细胞因子（IL-6：856±448 vs. 3283±943pg/ml；P<0.05）浓度升高。此外，接受大潮气量通气的老年动物比年轻动物有更严重的全身炎症反应（IL-1β：149±44 vs. 272±36pg/ml；P<0.05——分别为年轻与老年）。

结论

与年轻大鼠相比，使用非生理性大潮气量通气会使老年大鼠出现更多肺损伤。在发生VILI的老年动物中，肺部和全身炎症加重是一个关键发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aef/4056597/b3f13d322ffc/cc12744-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aef/4056597/07c964cc0e7c/cc12744-1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aef/4056597/7f02c4d19e64/cc12744-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aef/4056597/642058c2adfb/cc12744-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aef/4056597/315179a386d5/cc12744-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aef/4056597/b3f13d322ffc/cc12744-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aef/4056597/07c964cc0e7c/cc12744-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aef/4056597/e22c028b2c63/cc12744-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aef/4056597/2c8087d788ee/cc12744-3.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aef/4056597/642058c2adfb/cc12744-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aef/4056597/315179a386d5/cc12744-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aef/4056597/b3f13d322ffc/cc12744-7.jpg

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本文引用的文献

1
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JAMA. 2012 Oct 24;308(16):1651-9. doi: 10.1001/jama.2012.13730.
2
The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene.[60]富勒烯经反复口服延长大鼠寿命。
Biomaterials. 2012 Jun;33(19):4936-46. doi: 10.1016/j.biomaterials.2012.03.036. Epub 2012 Apr 10.
3
Functional disability 5 years after acute respiratory distress syndrome.
年龄相关性呼吸机相关性肺损伤：数学建模、实验数据和统计分析。
PLoS Comput Biol. 2024 Feb 22;20(2):e1011113. doi: 10.1371/journal.pcbi.1011113. eCollection 2024 Feb.
4
Prediction of respiratory complications by quantifying lung contusion volume using chest computed tomography in patients with chest trauma.采用胸部 CT 量化肺挫伤体积预测胸部创伤患者的呼吸并发症。
Sci Rep. 2023 Apr 19;13(1):6387. doi: 10.1038/s41598-023-33275-z.
5
S1P lyase inhibition prevents lung injury following high pressure-controlled mechanical ventilation in aging mice.S1P 裂解酶抑制可预防老龄小鼠高压控制机械通气后的肺损伤。
Exp Gerontol. 2023 Mar;173:112074. doi: 10.1016/j.exger.2022.112074. Epub 2022 Dec 22.
6
Differential Response of Pentanal and Hexanal Exhalation to Supplemental Oxygen and Mechanical Ventilation in Rats.大鼠戊醛和己醛呼出对补充氧气和机械通气的差异反应
Molecules. 2021 May 7;26(9):2752. doi: 10.3390/molecules26092752.
7
The Impact of Aging in Acute Respiratory Distress Syndrome: A Clinical and Mechanistic Overview.衰老对急性呼吸窘迫综合征的影响：临床与机制概述
Front Med (Lausanne). 2020 Oct 26;7:589553. doi: 10.3389/fmed.2020.589553. eCollection 2020.
8
Fluid restriction reduces pulmonary edema in a model of acute lung injury in mechanically ventilated rats.液体限制可减少机械通气大鼠急性肺损伤模型中的肺水肿。
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5
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J Leukoc Biol. 2010 Jun;87(6):1001-9. doi: 10.1189/jlb.0809542. Epub 2010 Mar 3.
7
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8
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Cytokine. 2009 Jul;47(1):48-55. doi: 10.1016/j.cyto.2009.04.004. Epub 2009 May 8.
9
Short-term exposure to high-pressure ventilation leads to pulmonary biotrauma and systemic inflammation in the rat.短期暴露于高压通气会导致大鼠发生肺生物创伤和全身炎症。
Int J Mol Med. 2008 Apr;21(4):513-9.
10
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Intensive Care Med. 2008 May;34(5):923-31. doi: 10.1007/s00134-007-0960-0. Epub 2008 Jan 5.