Liu Li-ping, Bai Jun, Wei Ya, Qi Xiao-dong, Si Ting-chen, Li Wei, Pan Hui
Department of pathology, Shunyi hospital, Beijing, China.
Zhonghua Bing Li Xue Za Zhi. 2013 Feb;42(2):101-5. doi: 10.3760/cma.j.issn.0529-5807.2013.02.007.
To investigate the clinicopathologic features and immunohistochemical of the basal-like subtype of invasive breast carcinoma (BLBC), and to discuss the diagnosis standard.
Immunohistochemistry was performed in 448 cases of breast carcinoma and these cases were categorized into luminal A, luminal B, null subtypes, HER2-overexpressing and basal-like and their clinicopathologic features were observed under light microscope with stains of HE and immunohistochemical InVitrogen staining.
Among the breast cancer patients, the incidence of BLBC was 15.4% (69/448). Morphologic features significantly associated with BLBC constituently included nest structure and showing diffuse growth pattern, large scarring areas without cells in tumor, geographic necrosis, pushing margin of invasion, lymphocytic infiltrate in various degree in tumor stroma, syncytial tumor cell without clear boundaries, tumor cell showing vesicular unclear chromatin and nucleolus, markedly elevated mitotic count, metaplasia (all P < 0.01). Meanwhile, most BLBC showed strong immunoreactivity for CK5/6, CK14, CK17 (all P < 0.01).
BLBC showed distinct morphologic and immunophenotypic features.
探讨浸润性乳腺癌基底样亚型（BLBC）的临床病理特征及免疫组化表现，并讨论其诊断标准。
对448例乳腺癌患者进行免疫组化检测，将这些病例分为腔面A型、腔面B型、三阴型、HER2过表达型和基底样型，在光学显微镜下用苏木精-伊红（HE）染色及免疫组化英潍捷基染色观察其临床病理特征。
在乳腺癌患者中，BLBC的发生率为15.4%（69/448）。与BLBC显著相关的形态学特征包括巢状结构并呈弥漫性生长模式、肿瘤内大片无细胞的瘢痕区、地图状坏死、浸润边缘呈推挤状、肿瘤间质内不同程度的淋巴细胞浸润、肿瘤细胞界限不清呈合体状、肿瘤细胞显示核染色质呈泡状且核仁不清晰、有丝分裂计数显著升高、化生（所有P<0.01）。同时，大多数BLBC对细胞角蛋白5/6（CK5/6）、细胞角蛋白14（CK14）、细胞角蛋白17（CK17）呈强免疫反应性（所有P<0.01）。
BLBC具有独特的形态学和免疫表型特征。
