Musellim Benan, Okumus Gulfer, Uzaslan Esra, Akgün Metin, Cetinkaya Erdogan, Turan Onur, Akkoclu Atila, Hazar Armagan, Kokturk Nurdan, Calisir Haluk Celalettin
Department of Pulmonary Diseases, Cerrahpasa Medical Faculty, Istanbul University, İstanbul, Turkey.
Clin Respir J. 2014 Jan;8(1):55-62. doi: 10.1111/crj.12035. Epub 2013 Jul 31.
There is very few data on the epidemiological features of interstitial lung diseases (ILD) in the literature. These studies on this subject suffer from limited number of patients.
The goal of this study was to evaluate the epidemiological features of ILD in Turkey.
Fifty-four investigators, 31 centres in 19 cities from six regions of Turkey, participated in the study. Two thousand two hundred forty-five newly diagnosed patients (51.8% females), led by Turkish Thoracic Society Clinical Problems Study Group, enrolled in this prospective study.
The mean age was 51.8 ± 16.7 years. The mean age among males was 50.5 ± 18.6 years and 53.0 ± 14.6 years among females (P < 0.001). 23.8% of the cases had ILD with known causes, while 39.4% were in granulomatous group, 23.7% were idiopathic, and 4.4% were in the unclassified group. Overall, histopathologically confirmed diagnosis rate was 40.4%. Sarcoidosis was the most common disease (37%), whereas cases with idiopathic pulmonary fibrosis (IPF) constituted 19,9% of patients. 53% of the sarcoidosis patients were females, and the ratio reaches to 75% under 50 years of age (for this group, IPF ratio is %3). In contrast, sarcoidosis and IPF ratios were equal in males (25%). Sarcoidosis was 8% in men over 50, while IPF was %45.
The overall incidence of ILD in Turkey was computed to be 25.8/100,000.
文献中关于间质性肺疾病（ILD）流行病学特征的数据非常少。这些关于该主题的研究患者数量有限。
本研究的目的是评估土耳其ILD的流行病学特征。
来自土耳其六个地区19个城市的31个中心的54名研究人员参与了该研究。由土耳其胸科学会临床问题研究小组牵头，2245名新诊断患者（51.8%为女性）纳入了这项前瞻性研究。
平均年龄为51.8±16.7岁。男性的平均年龄为50.5±18.6岁，女性为53.0±14.6岁（P<0.001）。23.8%的病例患有已知病因的ILD，而39.4%属于肉芽肿组，23.7%为特发性，4.4%属于未分类组。总体而言，组织病理学确诊率为40.4%。结节病是最常见的疾病（37%），而特发性肺纤维化（IPF）患者占19.9%。53%的结节病患者为女性，则50岁以下这一比例达到75%（该组中，IPF比例为3%）。相比之下，男性中结节病和IPF的比例相等（25%）。50岁以上男性中结节病占8%，而IPF占45%。
据计算，土耳其ILD的总体发病率为25.8/10万。
