关于15号染色体与叙利亚仓鼠恶性转化成纤维细胞系生物学特性之间关系的研究。
Studies on the relationship between chromosome No15 and the biological characteristics of malignant transformed Syrian hamster fibroblast cell lines.
作者信息
Li S, Liu B, Xu D
机构信息
Cancer Institute, CAMS, Beijing.
出版信息
Proc Chin Acad Med Sci Peking Union Med Coll. 1990;5(1):43-6.
During the course of malignant transformation of mammalian cells in vitro, a regular variation in chromosome number and structure is usually found. In order to elucidate the relationship between chromosomal changes and malignant expression, we isolated five clones from a malignant transformed Syrian hamster fibroblast cell line and analysed their biological characteristics, as well as chromosomal changes. A positive correlation between chromosome No 15 monosomy and the transformed and malignant phenotype was observed. We suggest that a suppression gene may be located on chromosome No 15, and its deletion or the loss of the chromosome may result in expression of the malignant phenotype.
在体外培养的哺乳动物细胞恶性转化过程中，通常会发现染色体数目和结构有规律的变化。为了阐明染色体变化与恶性表达之间的关系，我们从一个恶性转化的叙利亚仓鼠成纤维细胞系中分离出五个克隆，并分析了它们的生物学特性以及染色体变化。观察到15号染色体单体性与转化和恶性表型之间存在正相关。我们认为一个抑制基因可能位于15号染色体上，其缺失或该染色体的丢失可能导致恶性表型的表达。
Zotero 插件