Li S, Liu B, Xu D
Cancer Institute, CAMS, Beijing.
Proc Chin Acad Med Sci Peking Union Med Coll. 1990;5(1):43-6.
During the course of malignant transformation of mammalian cells in vitro, a regular variation in chromosome number and structure is usually found. In order to elucidate the relationship between chromosomal changes and malignant expression, we isolated five clones from a malignant transformed Syrian hamster fibroblast cell line and analysed their biological characteristics, as well as chromosomal changes. A positive correlation between chromosome No 15 monosomy and the transformed and malignant phenotype was observed. We suggest that a suppression gene may be located on chromosome No 15, and its deletion or the loss of the chromosome may result in expression of the malignant phenotype.
在体外培养的哺乳动物细胞恶性转化过程中，通常会发现染色体数目和结构有规律的变化。为了阐明染色体变化与恶性表达之间的关系，我们从一个恶性转化的叙利亚仓鼠成纤维细胞系中分离出五个克隆，并分析了它们的生物学特性以及染色体变化。观察到15号染色体单体性与转化和恶性表型之间存在正相关。我们认为一个抑制基因可能位于15号染色体上，其缺失或该染色体的丢失可能导致恶性表型的表达。
