β-桶状膜蛋白中的弱稳定区域和蛋白质-蛋白质相互作用
Weakly stable regions and protein-protein interactions in beta-barrel membrane proteins.
作者信息
Naveed Hammad, Liang Jie
机构信息
Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, 60607, USA.
出版信息
Curr Pharm Des. 2014;20(8):1268-73. doi: 10.2174/13816128113199990071.
Abstract
We briefly discuss recent progress in computational characterization of the sequence and structural properties of β-barrel membrane properties. We discuss the emerging concept of weakly stable regions in β-barrel membrane proteins, computational methods to identify these regions and mechanisms adopted by β-barrel membrane proteins in nature to stabilize them. We further discuss computational methods to identify protein-protein interactions in β-barrel membrane proteins and recent experimental studies that aim at altering the biophysical properties including oligomerization state and stability of β-barrel membrane proteins based on the emerging organization principles of these proteins from recent computational studies.
摘要
我们简要讨论了β-桶状膜蛋白序列和结构特性计算表征方面的最新进展。我们探讨了β-桶状膜蛋白中弱稳定区域这一新兴概念、识别这些区域的计算方法以及β-桶状膜蛋白在自然界中用于稳定它们的机制。我们还进一步讨论了识别β-桶状膜蛋白中蛋白质-蛋白质相互作用的计算方法，以及基于近期计算研究中这些蛋白新出现的组织原则，旨在改变β-桶状膜蛋白生物物理特性（包括寡聚化状态和稳定性）的最新实验研究。
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