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[受X射线照射的肠上皮细胞中黄嘌呤氧化酶转化的调节机制]

[Mechanisms of the regulation of the conversion of xanthine oxidase in enterocytes exposed to x-irradiation].

作者信息

Shelepina E I, Antonov V G, Kozhemiakin L A

出版信息

Radiobiologiia. 1990 May-Jun;30(3):328-31.

PMID:2371390
Abstract

X-Irradiation of rats has been shown to change electron acceptor properties of xanthine oxidase of enterocytes the tropism towards NAD being lost and that towards O2 increased. The transformation of xanthine oxidase forms depends on the oxidation level of glutathione. Excess concentrations of hypoxanthine are responsible for the xanthine oxidase O-form functioning.

摘要

已证明对大鼠进行X射线照射会改变肠细胞黄嘌呤氧化酶的电子受体特性,对NAD的趋向性丧失,而对O2的趋向性增加。黄嘌呤氧化酶形式的转变取决于谷胱甘肽的氧化水平。次黄嘌呤的过量浓度是黄嘌呤氧化酶O型发挥作用的原因。

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