Howell F, Kelly P, Clancy L
Peamount Hospital, Newcastle, Dublin, Ireland.
Respir Med. 1990 Mar;84(2):111-7. doi: 10.1016/s0954-6111(08)80012-1.
We present a retrospective epidemiological analysis of 1011 adults with a first time diagnosis of pulmonary TB seen between 1980-1985. Most (98.7%) were from the Republic of Ireland and 68.4% were male. Both males and females showed a bimodal age distribution with 37.6% of females and 18.8% of males aged younger than 30 years. More than half (58.6%) of patients smoked cigarettes and 63.7% consumed alcohol. Two patients indulged in the use of hard drugs. Only 5% of patients were asymptomatic and 0.9% of patients had symptoms for longer than 1 year. Radiologically, 54.7% of patients had bilateral disease; 58.5% had cavities and 10% had pleural effusions. Mantoux testing was positive to 1 tuberculin unit Mantoux in 76%; to 10 tuberculin units Mantoux in 15.3%; to 100 tuberculin units Mantoux in 3.7%; and negative to 100 tuberculin units in 5.0%. Primary drug resistance occurred in 0.9% of patients. Ninety (9.0%) of patients died before completing antituberculous treatment and in 40 patients tuberculosis was the principle or main cause of death.
我们对1980年至1985年间首次诊断为肺结核的1011名成年人进行了回顾性流行病学分析。大多数（98.7%）来自爱尔兰共和国，68.4%为男性。男性和女性均呈现双峰年龄分布，37.6%的女性和18.8%的男性年龄小于30岁。超过一半（58.6%）的患者吸烟，63.7%的患者饮酒。两名患者滥用硬性毒品。仅5%的患者无症状，0.9%的患者症状持续超过1年。放射学检查显示，54.7%的患者双侧患病；58.5%有空洞，10%有胸腔积液。结核菌素试验中，76%的患者对1个结核菌素单位呈阳性反应；15.3%的患者对10个结核菌素单位呈阳性反应；3.7%的患者对100个结核菌素单位呈阳性反应；5.0%的患者对100个结核菌素单位呈阴性反应。0.9%的患者出现原发性耐药。90名（9.0%）患者在完成抗结核治疗前死亡，40名患者中结核病是主要或首要死因。
