Burnett D, Hill S L, Bradwell A R, Stockley R A
Lung Immunobiochemical Research Laboratory, General Hospital, Birmingham, U.K.
Respir Med. 1990 Mar;84(2):123-7. doi: 10.1016/s0954-6111(08)80014-5.
The concentrations of IgA1 and IgA2 were measured in the serum and sputum from 27 clinically stable patients with bronchiectasis. Of the 27 patients, nine were regularly producing mucoid secretions, nine mucopurulent and nine purulent secretions. No significant differences were observed in serum IgA2 concentrations between the patient groups, although IgA1 concentrations were higher in the serum from the patients producing mucopurulent sputum than those producing mucoid or purulent sputum. The sputum concentrations of both IgA1 and IgA2 increased significantly with purulence. Furthermore, there was a significant increase in the proportion of IgA2 as the secretions became more purulent. The sputum concentrations of both IgA subclasses indicated significant local synthesis, with increased production (especially of IgA2) in the presence of inflammation due to infection.
对27例临床稳定的支气管扩张症患者的血清和痰液进行了IgA1和IgA2浓度检测。27例患者中，9例经常产生黏液样分泌物，9例产生黏液脓性分泌物，9例产生脓性分泌物。尽管产生黏液脓性痰液的患者血清中IgA1浓度高于产生黏液样或脓性痰液的患者，但患者组间血清IgA2浓度未观察到显著差异。IgA1和IgA2的痰液浓度均随脓性程度显著增加。此外，随着分泌物脓性程度增加，IgA2的比例显著增加。两种IgA亚类的痰液浓度均表明存在显著的局部合成，在感染引起炎症时产量增加（尤其是IgA2）。
