Division of Infectious Diseases, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC 20007, USA.
Infect Dis Clin North Am. 2013 Jun;27(2):359-77. doi: 10.1016/j.idc.2013.02.012. Epub 2013 Apr 6.
Intestinal and multivisceral transplantation has become an effective treatment option for patients with intestinal failure. More potent immunosuppressive therapy has resulted in a decreased incidence of acute rejection and has improved patient survival. However, infectious complications can cause significant morbidity both before and after transplantation. In comparison with other solid organ transplant recipients, these patients experience higher rates of acute allograft rejection, thus requiring higher levels of immunosuppression and escalating the risk of infection. This article reviews the most common infectious disease complications encountered, and proposes a potential temporal association for types of infections in this patient population.
肠和多器官移植已成为治疗肠衰竭患者的有效方法。更强效的免疫抑制疗法降低了急性排斥反应的发生率，并提高了患者的生存率。然而，感染并发症可导致移植前后出现严重的发病率。与其他实体器官移植受者相比，这些患者发生急性移植物排斥反应的比率更高，因此需要更高水平的免疫抑制，感染风险也随之增加。本文回顾了最常见的感染性疾病并发症，并提出了该患者人群中感染类型的潜在时间关联。
