Ansell Stephen M, Vonderheide Robert H
From the Division of Hematology, Mayo Clinic, Rochester, MN; Abrahamson Cancer Center of the University of Pennsylvania, Philadelphia, PA.
Am Soc Clin Oncol Educ Book. 2013. doi: 10.1200/EdBook_AM.2013.33.e91.
In addition to malignant cells, the tumor microenvironment also includes nonmalignant cells, secreted proteins, and blood vessels that surround and support the growth of the tumor. Interactions between the various components of the tumor microenvironment are significant; tumor cells can change the nature of the microenvironment, and conversely, the microenvironment can affect how a tumor grows and spreads. The structure and composition of the tumor microenvironment varies among different types of cancers and between patients. This paper focuses on the composition and function of the tumor microenvironment in hematologic malignancies with a specific focus on B-cell lymphomas.
除了恶性细胞外，肿瘤微环境还包括非恶性细胞、分泌蛋白以及围绕并支持肿瘤生长的血管。肿瘤微环境中各种成分之间的相互作用至关重要；肿瘤细胞可以改变微环境的性质，反之，微环境也会影响肿瘤的生长和扩散方式。肿瘤微环境的结构和组成在不同类型的癌症以及不同患者之间存在差异。本文重点关注血液系统恶性肿瘤中肿瘤微环境的组成和功能，尤其聚焦于B细胞淋巴瘤。
