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昼夜节律基因Per2在非小细胞肺癌中的表达及临床意义

[Expression and clinical significance of circadian gene Per2 in non-small cell lung cancer].

作者信息

Chi Chuang, He Zhi-feng, Liu Yu, Lin Xiao-ming, Sun Cheng-chao

机构信息

Department of Thoracic and Cardiovascular Surgery, the First Affiliated Hospital of Whenzhou Medical College, Wenzhou, China.

出版信息

Zhonghua Zhong Liu Za Zhi. 2013 Feb;35(2):129-31. doi: 10.3760/cma.j.issn.0253-3766.2013.02.011.

DOI:10.3760/cma.j.issn.0253-3766.2013.02.011
PMID:23714668
Abstract

OBJECTIVE

To detect the expression of Per2 in non-small cell lung cancer (NSCLC), and analyze its clinical significance.

METHODS

The expression of Per2 was determined in 60 NSCLC and 20 normal lung tissues by immunohistochemical assay, and the relationship between Per2 expression and clinicopathological features was analyzed.

RESULTS

The positive expression rates of Per2 in NSCLC and normal lung tissues were 71.7% and 95.0%, respectively (P < 0.05). The expression of Per2 in NSCLC was correlated with pathological differentiation and TNM stage (P < 0.05).

CONCLUSION

The expression of Per2 in NSCLC is decreased. The negative expression of Per2 may contribute to the development and invasion in NSCLC.

摘要

目的

检测周期蛋白2（Per2）在非小细胞肺癌（NSCLC）中的表达，并分析其临床意义。

方法

采用免疫组织化学法检测60例NSCLC组织和20例正常肺组织中Per2的表达，并分析Per2表达与临床病理特征的关系。

结果

NSCLC组织和正常肺组织中Per2的阳性表达率分别为71.7%和95.0%（P<0.05）。NSCLC中Per2的表达与病理分化程度和TNM分期相关（P<0.05）。

结论

NSCLC中Per2的表达降低。Per2的阴性表达可能促进NSCLC的发生发展和侵袭。

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引用本文的文献

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Low circadian clock genes expression in cancers: A meta-analysis of its association with clinicopathological features and prognosis.低节律钟基因表达与癌症：荟萃分析其与临床病理特征和预后的关系。
PLoS One. 2020 May 21;15(5):e0233508. doi: 10.1371/journal.pone.0233508. eCollection 2020.
2
Per2 participates in AKT-mediated drug resistance in A549/DDP lung adenocarcinoma cells.Per2参与A549/DDP肺腺癌细胞中AKT介导的耐药性。
Oncol Lett. 2017 Jan;13(1):423-428. doi: 10.3892/ol.2016.5430. Epub 2016 Nov 24.
3
Effects of Per2 overexpression on growth inhibition and metastasis, and on MTA1, nm23-H1 and the autophagy-associated PI3K/PKB signaling pathway in nude mice xenograft models of ovarian cancer.
过表达Per2对卵巢癌裸鼠移植瘤模型中生长抑制、转移以及MTA1、nm23-H1和自噬相关PI3K/PKB信号通路的影响。
Mol Med Rep. 2016 Jun;13(6):4561-8. doi: 10.3892/mmr.2016.5116. Epub 2016 Apr 13.