Altuntaş Emine Elif, Kaya Ali, Uysal Ismail Önder, Cevit Ömer, Içağasioğlu Dilara, Müderris Suphi
Department of Otorhinolaryngology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey.
J Craniofac Surg. 2013 May;24(3):e239-42. doi: 10.1097/SCS.0b013e318286084a.
Crimean-Congo hemorrhagic fever (CCHF), like other viral infections, may prolong mucociliary clearance time and increase nasal resistance in children. The aim of the present prospective case-control study was to study, using saccharin and anterior rhinomanometry tests, whether CCHF infections caused any change in nasal physiology.
Overall, 40 subjects, 20 of whom had CCHF (group 1) and 20 of whom were healthy controls (group 2), were enrolled in this study. The definitive diagnosis of CCHF infection was made based on typical clinical and epidemiological findings and detection of CCHF virus-specific IgM by ELISA or of genomic segments of the CCHF virus by reverse transcription-polymerase chain reaction. Anterior rhinomanometry was performed in all participants according to current recommendations of the Committee Report on Standardization of Rhinomanometry. A saccharin test was used to evaluate mucociliary clearance, and nasal mucociliary clearance time was assessed with the saccharin test as described previously.
In our patients, the mean time from the application of saccharin crystals to the first feeling of a sweet taste was 6.77 ± 3.25 minutes (range 2-16 min). In terms of the mean time from the application of saccharin crystals to the first feeling of a sweet taste, there was no difference between two groups. The mean total air flow was 637.60 ± 76.18 mL/s (range 490-760 mL/s). The mean total nasal airway resistance was 0.24 ± 0.03 Pa/mL s (range 0.20-0.31 Pa/mL s). In terms of the degree of nasal air flow and nasal airway resistance and the total air flow and total nasal airway resistance of each nostril, there was no difference between the 2 groups.
The results obtained in anterior rhinomanometry and saccharin test showed that there was no statistically significant difference between CCHF (+) patients and controls. These results suggest us that CCHF virus infection does not affect nasal physiology. However, this is the first study performed on this issue and further studies on larger series need to be performed.
与其他病毒感染一样，克里米亚-刚果出血热（CCHF）可能会延长儿童的黏液纤毛清除时间并增加鼻阻力。本前瞻性病例对照研究的目的是通过糖精试验和前鼻测压法研究CCHF感染是否会引起鼻腔生理变化。
本研究共纳入40名受试者，其中20名患有CCHF（第1组），20名作为健康对照（第2组）。CCHF感染的确诊基于典型的临床和流行病学表现，以及通过酶联免疫吸附测定法检测CCHF病毒特异性IgM或通过逆转录聚合酶链反应检测CCHF病毒的基因组片段。根据鼻测压标准化委员会报告的当前建议，对所有参与者进行前鼻测压。使用糖精试验评估黏液纤毛清除情况，并如前所述用糖精试验评估鼻腔黏液纤毛清除时间。
在我们的患者中，从应用糖精晶体到首次感觉到甜味的平均时间为6.77±3.25分钟（范围为2 - 16分钟）。就从应用糖精晶体到首次感觉到甜味的平均时间而言，两组之间没有差异。平均总气流为637.60±76.18 mL/s（范围为490 - 760 mL/s）。平均总鼻气道阻力为0.24±0.03 Pa/mL·s（范围为0.20 - 0.31 Pa/mL·s）。就每个鼻孔的鼻气流程度、鼻气道阻力以及总气流和总鼻气道阻力而言，两组之间没有差异。
前鼻测压和糖精试验获得的结果表明，CCHF（+）患者与对照组之间在统计学上没有显著差异。这些结果表明，CCHF病毒感染不会影响鼻腔生理。然而，这是关于该问题的首次研究，需要对更大样本量进行进一步研究。
