糖酵解酶及葡萄糖-6-磷酸脱氢酶在平滑肌增殖中的活性

Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in smooth muscle proliferation.

作者信息

Elbers J R, Rijksen G, Staal G E, van Unnik J A, Roholl P J, van Oirschot B A, Oosting J

机构信息

Department of Pathology, St. Antonius Hospital, Nieuwegein, The Netherlands.

出版信息

Tumour Biol. 1990;11(4):210-9. doi: 10.1159/000217657.

DOI:10.1159/000217657

PMID:2371498

Abstract

The specific activity of hexokinase, phosphofructokinase, aldolase, enolase, pyruvate kinase and glucose-6-phosphate dehydrogenase was measured in 41 smooth muscle cell tumors: 20 leiomyomas and 21 cases of leiomyosarcoma. Statistical analysis revealed no significant differences in specific activity between normal smooth muscle tissue and the benign and malignant tumors originating from it. Quantification of the isozyme composition of pyruvate kinase showed a significant shift in isozyme pattern towards K-type subunits in leiomyosarcomas as compared to leiomyomas.

摘要

在41例平滑肌细胞瘤中测定了己糖激酶、磷酸果糖激酶、醛缩酶、烯醇化酶、丙酮酸激酶和葡萄糖-6-磷酸脱氢酶的比活性，其中包括20例平滑肌瘤和21例平滑肌肉瘤。统计分析显示，正常平滑肌组织与其来源的良性和恶性肿瘤之间的比活性无显著差异。丙酮酸激酶同工酶组成的定量分析表明，与平滑肌瘤相比，平滑肌肉瘤的同工酶模式向K型亚基有显著转变。