Wellcome Trust-MRC Cambridge Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.
Development. 2013 Jun;140(12):2562-75. doi: 10.1242/dev.092262.
The growing burden of the rapidly ageing global population has reinvigorated interest in the science of ageing and rejuvenation. Among organ systems, rejuvenation of the central nervous system (CNS) is arguably the most complex and challenging of tasks owing, among other things, to its startling structural and functional complexity and its restricted capacity for repair. Thus, the prospect of meaningful rejuvenation of the CNS has seemed an impossible goal; however, advances in stem cell science are beginning to challenge this assumption. This Review outlines these advances with a focus on ageing and rejuvenation of key endogenous stem and progenitor cell compartments in the CNS. Insights gleaned from studies of model organisms, chiefly rodents, will be considered in parallel with human studies.
全球人口迅速老龄化带来的负担日益加重，这重新激发了人们对衰老和恢复活力科学的兴趣。在各个器官系统中，中枢神经系统 (CNS) 的恢复活力可以说是最复杂和最具挑战性的任务之一，这主要是由于其惊人的结构和功能复杂性以及其有限的修复能力。因此，CNS 有意义的恢复活力的前景似乎是一个不可能实现的目标；然而，干细胞科学的进步开始挑战这一假设。本综述概述了这些进展，重点关注 CNS 中关键内源性干细胞和祖细胞区室的衰老和恢复活力。从主要是啮齿动物的模式生物研究中获得的见解将与人类研究一起进行考虑。
