Rheumatology, Department of Internal Medicine, Juntendo University Koshigaya Hospital, 560 Fukuroyama, Koshigaya, Saitama, 343-0032, Japan.
Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Clin Exp Nephrol. 2013 Oct;17(5):611-614. doi: 10.1007/s10157-013-0813-9. Epub 2013 May 30.
The epidemiology of systemic vasculitides differs between Japan, Europe and North America. Takayasu's arteritis occurs frequently in Japan, unlike giant cell arteritis. A collaborative international study comparing the epidemiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis between Japan and the United Kingdom (UK) demonstrated that microscopic polyangiitis and myeloperoxidase-ANCA were more common in Japan, whereas granulomatosis with polyangiitis and pronase 3-ANCA were more common in the UK. These differences may be attributed to differences in latitude and genetic backgrounds. These findings provide useful information on the aetiology and pathogenesis of primary systemic vasculitides in various geographical regions.
系统性血管炎的流行病学在日本、欧洲和北美有所不同。与巨细胞动脉炎不同，高安氏动脉炎在日本较为常见。一项比较日本和英国抗中性粒细胞胞浆抗体（ANCA）相关性血管炎流行病学的国际合作研究表明，显微镜下多血管炎和髓过氧化物酶-ANCA 在日本更为常见，而肉芽肿性多血管炎和蛋白酶 3-ANCA 在英国更为常见。这些差异可能归因于纬度和遗传背景的不同。这些发现为不同地理区域原发性系统性血管炎的病因和发病机制提供了有用信息。
