Brown D, Garner W, Young V L
Division of Plastic Surgery, Washington University School of Medicine, St. Louis, MO 63110.
South Med J. 1990 Jul;83(7):789-95. doi: 10.1097/00007611-199007000-00018.
The inhibition of wound contraction by skin grafting is widely accepted but poorly understood. We used an experimental model of contraction to study the effect of dermal organization, cellularity, and collagen matrix on contraction inhibition. Wound beds covered with inverted and collagen matrix grafts contracted at the same rate as full-thickness grafts. Heat denaturation diminished this ability. Partial-thickness grafts derived from papillary or reticular dermis inhibited contraction to an equal degree. Inhibition of contraction appears to relate to the amount of intact dermal collagen matrix transferred, and not to another component of a full-thickness graft.
皮肤移植对伤口收缩的抑制作用已被广泛认可，但人们对此了解甚少。我们使用了一种收缩实验模型来研究真皮组织、细胞密度和胶原基质对收缩抑制的影响。覆盖有反转和胶原基质移植物的伤口床收缩速度与全层移植物相同。热变性降低了这种能力。源自乳头层或网状真皮的部分厚度移植物对收缩的抑制程度相同。收缩抑制似乎与转移的完整真皮胶原基质的量有关，而与全层移植物的其他成分无关。
