Department of Pediatrics, Kawasaki Medical School, Okayama, Japan.
Antimicrob Agents Chemother. 2013 Aug;57(8):4046-9. doi: 10.1128/AAC.00663-13. Epub 2013 May 28.
We conducted nationwide surveillance to investigate regional differences in macrolide-resistant (MR) Mycoplasma pneumoniae strains in Japan. The prevalence of MR M. pneumoniae in pediatric patients gradually increased between 2008 and 2012. Although regional differences were observed, high levels of MR genes were detected in all seven surveillance areas throughout Japan and ranged in prevalence from 50% to 93%. These regional differences were closely related to the previous administration of macrolides.
我们进行了全国范围的监测，以调查日本肺炎支原体耐药（MR）株的地区差异。在 2008 年至 2012 年期间，儿科患者中 MR 肺炎支原体的流行率逐渐增加。虽然观察到了地区差异，但在日本所有七个监测地区均检测到高水平的 MR 基因，流行率从 50%到 93%不等。这些地区差异与先前使用大环内酯类抗生素密切相关。
