Basu Shyamoshree, Maity S
Department of Pharmaceutical Technology, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata-Group of Institutions, Kolkata-700 053, India.
Indian J Pharm Sci. 2012 Sep;74(5):428-33. doi: 10.4103/0250-474X.108418.
The aim of the present study is to prepare and evaluate mucoadhesive nasal gels of venlafaxine hydrochloride. Mucoadhesive nasal gels were prepared using polymers like carbopol 934 and sodium alginate and characterized in terms of viscosity, texture profile analysis, ex vivo drug permeation profiles and histopathological studies. The results show that values of viscosity, hardness and adhesiveness increase while those of cohesiveness decrease with corresponding increase in concentration of the polymers. Ex vivo drug permeation profiles showed that formulation containing 5% sodium alginate provided a better controlled release of the drug than the other formulations over a period of 12 h. Histopathological studies assured that gels containing different polymers did not produce any significant change in the nasal mucosae of goat even after 12 h permeation study. Mucoadhesive nasal gel of venlafaxine hydrochloride is a novel dosage form which delivers the drug directly into systemic circulation and provides controlled release of the drug.
本研究的目的是制备并评估盐酸文拉法辛的黏膜黏附性鼻用凝胶。使用卡波姆934和海藻酸钠等聚合物制备黏膜黏附性鼻用凝胶，并对其进行黏度、质地剖面分析、体外药物渗透曲线和组织病理学研究等方面的表征。结果表明，随着聚合物浓度的相应增加，黏度、硬度和黏附性的值增加，而内聚性的值降低。体外药物渗透曲线表明，含5%海藻酸钠的制剂在12小时内比其他制剂能更好地控制药物释放。组织病理学研究表明，即使经过12小时的渗透研究，含不同聚合物的凝胶在山羊鼻黏膜中也未产生任何显著变化。盐酸文拉法辛黏膜黏附性鼻用凝胶是一种新型剂型，可将药物直接输送至体循环并实现药物的控释。
